Mouse Killer Cell Immunoglobulin-Like Receptor Monoclonal Antibody | anti-KIR2DS4 antibody

Mouse Anti Human Killer Cell Immunoglobulin-Like Receptor, 2 Domains Short Cytoplasmic Tail 4

Cat. Num. AAA140181

• Gene Names: KIR2DS4; KKA3; KIR1D; NKAT8; CD158I; KIR412; NKAT-8; KIR2DS1
• Applications: ELISA, Western Blot
• Purity: KIR2DS4 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Synonyms: Killer Cell Immunoglobulin-Like Receptor; Monoclonal Antibody; Mouse Anti Human Killer Cell Immunoglobulin-Like Receptor; 2 Domains Short Cytoplasmic Tail 4; KIR2DS4 Antibody; Killer Cell Immunoglobulin-Like Receptor 2 Domains Short Cytoplasmic Tail 4; Mouse Anti Human; Killer cell immunoglobulin-like receptor 2DS4; MHC class I NK cell receptor; Natural killer-associated transcript 8; NKAT-8; P58 natural killer cell receptor clone CL-39; p58 NK receptor; CL-17; CD158 antigen-like family member I; CD158i antigen; KIR2DS4; CD158I; KKA3; NKAT8; KIR1D; KIR412; MGC120019; MGC125315; MGC125317; anti-KIR2DS4 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b heavy chain and kappa light chain
• Clone Number: P5F2AT
• Purity/Purification: KIR2DS4 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Form/Format: 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
• Sequence Length: 304

• Applicable Applications for anti-KIR2DS4 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: KIR2DS4 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 2,000. Recommended starting dilution is 1:1,000.
• Immunogen: Anti-human KIR2DS4 mAb is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human KIR2DS4 purified from E Coli.
• Preparation and Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.; 12 months at -20 degree C. 1 month at 4 degree C.

Related Product Information for anti-KIR2DS4 antibody

Introduction: Killer-cell immunoglobulin-like receptors (KIRs), are a family of cell surface glycoproteins found on Natural Killer (NK) Cells, which are important cells of the immune system. They control the killing function of these cells by interacting with MHC class I molecules, which are expressed on all cell types. This interaction allows them to identify virally infected cells or tumor cells that have a distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, which means that their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. The KIR genes are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). KIR molecules are extremely polymorphic, meaning their gene sequences differ significantly between individuals, so that different individuals have different arrays/repertoires of KIR genes. The KIR proteins are categorized by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM). Whereas KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. KIR2DS4 is an activating Killer Cell Ig-like Receptor (KIR, previously called p50 KIR, p50.3, cl39, or KAR-K1), which may recognize class I MHC molecules. KIR2DS4 does not inhibit the activity of NK cells.

Product Categories/Family for anti-KIR2DS4 antibody

Monoclonal/Polyclonal Antibodies; Monoclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 116517309
• NCBI GeneID: 3809
• NCBI Accession #: NP_036446.3
• NCBI GenBank Nucleotide #: NM_012314.5
• Molecular Weight: 33,583 Da
• NCBI Official Full Name: killer cell immunoglobulin-like receptor 2DS4 isoform 1
• NCBI Official Synonym Full Names: killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
• NCBI Official Symbol: KIR2DS4
• NCBI Official Synonym Symbols: KKA3; KIR1D; NKAT8; CD158I; KIR412; NKAT-8; KIR2DS1
• NCBI Protein Information: killer cell immunoglobulin-like receptor 2DS4; CD158 antigen-like family member I; KIR antigen 2DS4; MHC class I NK cell receptor; P58 natural killer cell receptor clones CL-39/CL-17; killer Ig receptor; killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 1; killer inhibitory receptor 4-1-2; natural killer cell inhibitory receptor; natural killer-associated transcript 8; p58 NK receptor CL-39/CL-17
• UniProt Protein Name: Killer cell immunoglobulin-like receptor 2DS4
• Protein Family: Killer cell immunoglobulin-like receptor
• UniProt Gene Name: KIR2DS4
• UniProt Synonym Gene Names: CD158I; KKA3; NKAT8; NKAT-8; p58 NK receptor CL-39/CL-17
• UniProt Entry Name: KI2S4_HUMAN

NCBI Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

Uniprot Description

KIR2DS4: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Belongs to the immunoglobulin superfamily.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to plasma membrane; plasma membrane

Biological Process: innate immune response