Mouse JUN Monoclonal Antibody | anti-JUN antibody

JUN Monoclonal Antibody

Cat. Num. AAA2549091

• Gene Names: JUN; AP1; p39; AP-1; c-Jun
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: Protein G Purification
• Synonyms: JUN; Monoclonal Antibody; JUN Monoclonal Antibody; Activator protein 1; AP 1; AP1; c Jun; jun oncogene; P39; Proto oncogene c Jun; Transcription factor AP 1; anti-JUN antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 1G6B11
• Purity/Purification: Protein G Purification
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 2594

• Applicable Applications for anti-JUN antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:1000-1:10000
• Immunogen: Fusion Protein of JUN
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, PH7.3
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of RAW 264.7 cells using JUN Monoclonal Antibody at dilution of 1:4000)

Related Product Information for anti-JUN antibody

JUN is also named as c-Jun and AP1, belongs to the bZIP family and Jun subfamily. JUN, the most extensively studied protein of the activator protein-1 (AP-1) complex, is involved in numerous cell activities, such as proliferation, apoptosis, survival, tumorigenesis and tissue morphogenesis. JUN is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. JUN is a basic leucine zipper (bZIP) transcription factor that acts as homo- or heterodimer, binding to DNA and regulating gene transcription. In additon, extracellular signals can induce post-translational modifications of JUN, resulting in altered transcriptional activity and target gene expression. More over, it has uncovered multiple layers of a complex regulatory scheme in which JUN is able to crosstalk, amplify and integrate different signals for tissue development and disease. Jun is predominantly nuclear, ubiquitinated Jun colocalizes with lysosomal proteins.

Product Categories/Family for anti-JUN antibody

Cancer

NCBI and Uniprot Product Information

• NCBI GI #: 46329589
• NCBI GeneID: 3725
• UniProt Accession #: P05412; Q6FHM7; Q96G93
• Molecular Weight: Calculated Molecular Weight: 331aa; 36kDa; Observed Molecular Weight: 39kDa
• NCBI Official Full Name: Homo sapiens jun oncogene, mRNA
• NCBI Official Synonym Full Names: Jun proto-oncogene, AP-1 transcription factor subunit
• NCBI Official Symbol: JUN
• NCBI Official Synonym Symbols: AP1; p39; AP-1; c-Jun
• NCBI Protein Information: transcription factor AP-1
• UniProt Protein Name: Transcription factor AP-1
• Protein Family: Junctophilin
• UniProt Gene Name: JUN
• UniProt Synonym Gene Names: AP1

NCBI Description

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]

Uniprot Description

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).