Mouse anti-Human JAM-A/F11R Monoclonal Antibody | anti-JAM-A/F11R antibody

Mouse anti Human JAM-A/F11R Monoclonal Antibody

Cat. Num. AAA2543279

• Gene Names: F11R; JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1
• Reactivity: Human
• Applications: Immunocytochemistry, Immunofluorescence, Flow Cytometry, Functional Assay
• Synonyms: JAM-A/F11R; Monoclonal Antibody; Mouse anti Human JAM-A/F11R Monoclonal Antibody; anti-JAM-A/F11R antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Sequence Length: 250

• Applicable Applications for anti-JAM-A/F11R antibody: Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cyometry (FC/FACS)
• Application Notes: Flow Cytometry: 0.5-2 mug/Test; ICC/IF: 10-25 mug/mL
• Immunogen: Recombinant Human JAM-A/F11R/CD321 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 1129371461
• NCBI GeneID: 50848
• NCBI GenBank Nucleotide #: NM_001348091.1
• Molecular Weight: 27,208 Da
• NCBI Official Full Name: junctional adhesion molecule A isoform 6
• NCBI Official Synonym Full Names: F11 receptor
• NCBI Official Symbol: F11R
• NCBI Official Synonym Symbols: JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1
• NCBI Protein Information: junctional adhesion molecule A
• UniProt Protein Name: Junctional adhesion molecule A
• UniProt Gene Name: F11R
• UniProt Synonym Gene Names: JAM1; JCAM; JAM-A; JAM-1; PAM-1
• UniProt Entry Name: JAM1_HUMAN

NCBI Description

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

Uniprot Description

JAM-A: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Belongs to the immunoglobulin superfamily.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q21.2-q21.3

Cellular Component: cell junction; cell-cell adherens junction; intercellular junction; microtubule cytoskeleton; plasma membrane; tight junction

Molecular Function: PDZ domain binding; protein binding

Biological Process: actomyosin structure organization and biogenesis; extracellular matrix organization and biogenesis; inflammatory response; intestinal absorption; leukocyte migration; positive regulation of GTPase activity; transforming growth factor beta receptor signaling pathway