Immunohistochemistry (IHC)
(Anti-ISL1 / Islet 1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.)
Mouse anti-Human ISLET-1 / ISL1 Monoclonal Antibody | anti-ISLET-1 antibody
Mouse Monoclonal [clone 1H9] (IgG1) to Human ISLET-1 / ISL1
Immunohistochemistry (IHC)
(Anti-ISL1 / Islet 1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.)
Immunohistochemistry (IHC)
(Anti-ISL1 / Islet 1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.)
Immunohistochemistry (IHC)
(Anti-ISL1 / Islet 1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.)
Immunohistochemistry (IHC)
(Anti-ISL1 / Islet 1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.)
Western Blot (WB)
(IHC of paraffin-embedded human lung cancer (left) and cervical carcinoma (right), showing nuclear localization using anti-ISL1 antibody with DAB staining.)
Western Blot (WB)
(IHC of paraffin-embedded human lung cancer (left) and cervical carcinoma (right), showing nuclear localization using anti-ISL1 antibody with DAB staining.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]
Uniprot Description
ISL1: Binds to one of the cis-acting domain of the insulin gene enhancer.
Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Cell development/differentiation; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 5q11.1
Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus
Molecular Function: ligand-dependent nuclear receptor binding; zinc ion binding; bHLH transcription factor binding; estrogen receptor binding; chromatin binding
Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of interleukin-12 production; positive regulation of interleukin-1 alpha production; negative regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of estrogen receptor signaling pathway; pancreas development; positive regulation of cell proliferation; neuron fate specification; ventricular cardiac muscle morphogenesis; negative regulation of neuron apoptosis; sensory system development; neural crest cell migration; positive regulation of DNA binding; trigeminal nerve development; pharyngeal system development; axon regeneration; spinal cord motor neuron cell fate specification; positive regulation of insulin secretion; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; spinal cord motor neuron differentiation; positive regulation of interleukin-1 beta production; positive regulation of angiogenesis; negative regulation of neuron differentiation; positive regulation of interferon-gamma production; mesenchymal cell differentiation; visceral motor neuron differentiation; pituitary gland development; negative regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; peripheral nervous system neuron axonogenesis; retinal ganglion cell axon guidance
Research Articles on ISLET-1
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Product Notes
The ISLET-1 isl1 (Catalog #AAA246283) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Monoclonal [clone 1H9] (IgG1) to Human ISLET-1 / ISL1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ISLET-1 / ISL1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA). ELISA (1:10000), IF (1:200 - 1:1000), IHC-P (1:200), WB (1:500 - 1:2000). Researchers should empirically determine the suitability of the ISLET-1 isl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ISLET-1 / ISL1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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