Mouse anti-Human Interleukin-16 (IL-16) Monoclonal Antibody | anti-IL-16 antibody

Anti-Interleukin-16 (IL-16) Antibody

Cat. Num. AAA418396

• Gene Names: IL16; LCF; NIL16; PRIL16; prIL-16
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified by protein A affinity chromatography.
• Synonyms: Interleukin-16 (IL-16); Monoclonal Antibody; Anti-Interleukin-16 (IL-16) Antibody; anti-IL-16 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Purity/Purification: Purified by protein A affinity chromatography.
• Form/Format: Liquid
• Concentration: 1ug/ul (varies by lot)
• Sequence Length: 1331

• Applicable Applications for anti-IL-16 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Ni-NTA purified recombinant human IL-16 expressed in E Coli strain BL21 (DE3).
• Storage Buffer: PBS, pH 7.4 with 0.05% sodium azide.
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Western Blot (WB)

Related Product Information for anti-IL-16 antibody

Interleukin-16, also known as lymphocyte chemoattractant factor (LCF), is a chemotactic cytokine that stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils through binding to the CD4 receptor. IL-16 induces human T-lymphocyte expression of interleukin 2 receptor and upregurates major histocompatibility complex ?molecules on resting human T lymphocyte. It is able to render CD4+ T cells unresponsive to TCR/CD3 stimuli. Moreover, IL-16 inhibits the replication of T cell and monocyte tropic HIV strains in vitro.

References

1. Cruikshank, W.W. et al 1994. Proc. Nat. Acad. Sci. 91: 5109-5113, PubMed ID : 7910967

NCBI and Uniprot Product Information

• NCBI GI #: 223460532
• NCBI GeneID: 3603
• Molecular Weight: 59,345 Da
• NCBI Official Full Name: IL16 protein
• NCBI Official Synonym Full Names: interleukin 16
• NCBI Official Symbol: IL16
• NCBI Official Synonym Symbols: LCF; NIL16; PRIL16; prIL-16
• NCBI Protein Information: pro-interleukin-16
• UniProt Protein Name: Pro-interleukin-16
• UniProt Gene Name: IL16
• UniProt Synonym Gene Names: IL-16; LCF

NCBI Description

The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Uniprot Description

IL16: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. 3 isoforms of the human protein are produced by alternative promoter.

Protein type: Cytokine; DNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q25.1

Cellular Component: cytoplasm; cytosol; extracellular region; nucleus; plasma membrane

Biological Process: immune response