Testing Data
(PBMCs were stained with MBS6007282 or APC-conjugated isotype control. Histograms were gated on monocytes.)
Mouse anti-Mouse Interleukin 10R, beta Monoclonal Antibody | anti-IL10RB antibody
Interleukin 10R, beta (IL-10 R-beta, Interleukin 10 Receptor beta, IL-10R2, CD210b, CRF2-4) (APC)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Testing Data
(PBMCs were stained with MBS6007282 or APC-conjugated isotype control. Histograms were gated on monocytes.)
Testing Data
(PBMCs were stained with MBS6007282 or APC-conjugated isotype control. Histograms were gated on monocytes.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
Uniprot Description
IL10RB: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IL29. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Belongs to the type II cytokine receptor family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component: integral to membrane; plasma membrane; interleukin-28 receptor complex
Molecular Function: protein binding; interleukin-10 receptor activity; receptor activity
Biological Process: cytokine and chemokine mediated signaling pathway; immune response; signal transduction; inflammatory response; defense response to virus
Disease: Inflammatory Bowel Disease 25, Autosomal Recessive; Hepatitis B Virus, Susceptibility To
Research Articles on IL10RB
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Product Notes
The IL10RB il10rb (Catalog #AAA6007282) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Interleukin 10R, beta (IL-10 R-beta, Interleukin 10 Receptor beta, IL-10R2, CD210b, CRF2-4) (APC) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Interleukin 10R, beta can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Suitable for use in Flow Cytometry. Researchers should empirically determine the suitability of the IL10RB il10rb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Interleukin 10R, beta, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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