Mouse anti-Human Interferon alpha-1 (IFNA1) Monoclonal Antibody | anti-IFNA1 antibody
Interferon alpha-1 (IFNA1) Mouse Monoclonal Antibody
Reactivity
Human
Applications
Flow Cytometry, Functional Assay, Immunofluorescence
Synonyms
Interferon alpha-1 (IFNA1); Monoclonal Antibody; Interferon alpha-1 (IFNA1) Mouse Monoclonal Antibody; IFN alpha; IFN alpha 1/13; IFN alpha 1b; Interferon alpha 13 (IFNA13); Interferon alpha leukocyte (IFL); Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-D (IFN alphaD); Interferon alpha1 (IFNA1); LeIF D; anti-IFNA1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
2.52
Specificity
This MAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- & Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
190
Applicable Applications for anti-IFNA1 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Immunofluorescence (0.5-1ug/ml)
Cellular Localization
Cytoplasmic & Extracellular (Secreted)
Immunogen
Purified recombinant human IFN-alpha1
Hu-Chromosome Location
9q22
Positive Control
Stimulated human peripheral blood mononuclear cells
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
References
Pestka S et al. Interferons and their actions. Annu Rev Biochem 1987, 56:727-777 Sen GC et al.The interferon system. A bird's eye view of its biochemistry. J Biol Chem 1992, 267(8):5017-5020 Capon DJ et al. Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides. Mol Cell Biol 1985, 5(4):768-779 Kurane I et al. Induction of interferon alpha from human lymphocytes by autologous, dengue virus-infected monocytes. J Exp Med 1987, 166(4):999-1010 Lepe-Zuniga JL et al. Production of interferon-alpha induced by dsRNA in human peripheral blood mononuclear cell cultures: role of priming by dsRNA-induced interferons-gamma and -beta. J Interferon Res 1989, 9(4):445-456 Aman MJ et al. Interferon-alpha stimulates production of interleukin-10 in activated CD4+ T cells and monocytes. Blood 1996, 87(11):4731-473
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
16-27kDa
NCBI Official Full Name
interferon alpha-1/13
NCBI Official Synonym Full Names
interferon alpha 13
NCBI Official Symbol
IFNA13
NCBI Protein Information
interferon alpha-1/13
UniProt Protein Name
Interferon alpha-1/13
Protein Family
UniProt Gene Name
IFNA1
UniProt Synonym Gene Names
IFN-alpha-1/13; LeIF D
UniProt Entry Name
IFNA1_HUMAN
Uniprot Description
IFNA1/13: a cytokine that belongs to the alpha/beta interferon family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 9p22
Cellular Component: extracellular region; extracellular space
Molecular Function: cytokine activity; interferon-alpha/beta receptor binding
Biological Process: adaptive immune response; B cell differentiation; B cell proliferation; blood coagulation; cytokine and chemokine mediated signaling pathway; humoral immune response; innate immune response; natural killer cell activation during immune response; positive regulation of peptidyl-serine phosphorylation of STAT protein; response to exogenous dsRNA; T cell activation during immune response
Research Articles on IFNA1
1. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
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Product Notes
The IFNA1 ifna1 (Catalog #AAA438530) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Interferon alpha-1 (IFNA1) Mouse Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Interferon alpha-1 (IFNA1) can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunofluorescence (IF). Flow Cytometry (0.5-1ug/million cells in 0.1ml) Immunofluorescence (0.5-1ug/ml). Researchers should empirically determine the suitability of the IFNA1 ifna1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Interferon alpha-1 (IFNA1), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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