Mouse anti-Human Integrin beta1, Adhesion Stimulating Monoclonal Antibody | anti-ITGB1 antibody
Integrin beta1, Adhesion Stimulating
Purified immunoglobulin from Protein A Sepharose chromatography
Purified immunoglobulin from Protein A Sepharose chromatography
NCBI and Uniprot Product Information
Uniprot Description
ITGB1: an integral membrane protein that heterodimerizes with an alpha-3 chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. . Beta 1 integrins recognize the amino-acid motif RGD in a wide array of ligands. Five alternatively spliced variants with alternate carboxy termini have been described. Two alternatively spliced isoforms have been described. Isoform beta-1a is widely expressed; other isoforms are generally expressed with a more restricted distribution. Isoform beta-1b is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoforms beta-1c and beta-1c-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-c-2, rather than isoform beta-1c, is selectively expressed in primary t-cells. Isoform beta-1c is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1d is expressed specifically in striated muscle (skeletal and cardiac muscle).
Protein type: Receptor, misc.; Cell adhesion; Cell surface; Motility/polarity/chemotaxis; Membrane protein, integral
Cellular Component: lamellipodium; plasma membrane; melanosome; integrin complex; cell junction
Molecular Function: protein binding; metal ion binding; receptor activity
Biological Process: integrin-mediated signaling pathway; multicellular organismal development; cell-matrix adhesion
Research Articles on ITGB1
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Product Notes
The ITGB1 itgb1 (Catalog #AAA602791) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Integrin beta1, Adhesion Stimulating reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Integrin beta1, Adhesion Stimulating can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). Immunoprecipitation, Immunohistochemistry on frozen sections, Flow cytometry, Stimulates adhesion of cells to extracellular matrix proteins1, Does not bind reduced b1 integrin on Western blot. Researchers should empirically determine the suitability of the ITGB1 itgb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Integrin beta1, Adhesion Stimulating, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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