Insulin Like Growth Factor I (IGF-I) Somatomedin C Monoclonal Antibody | anti-IGF1 antibody

MAb to Somatomedin C

Cat. Num. AAA310659

• Gene Names: IGF1; IGFI; IGF-I; IGF1A
• Reactivity: ILGF-1: 100%; ILGF-2: 1%; Proinsulin: 1.4%; MSF: 1%; Insulin: <0.1%
• Purity: Protein A chromatography
• Synonyms: Insulin Like Growth Factor I (IGF-I) Somatomedin C; Monoclonal Antibody; MAb to Somatomedin C; Monoclonal Antibody to Human Insulin-Like Growth Factor Type I (IGF-1); Somatomedin C; anti-IGF1 antibody

• Host: Host: Mouse; Source: Tissue Culture Supernatant
• Reactivity: ILGF-1: 100%; ILGF-2: 1%; Proinsulin: 1.4%; MSF: 1%; Insulin: <0.1%
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: BM23
• Specificity: Insulin Like Growth Factor I (IGF-I) Somatomedin C; The basic IGF-1-like forms (pI>9.0) showed substantial cross-reactivity, as did rat and mouse sera. Monoclonal antibody BM23 was capable of abolishing the biological activities of IGF-1 in-vitro bioassays for insulin-like, mitogenic and sulphation activities.
• Purity/Purification: Protein A chromatography
• Form/Format: Purified, Liquid
• Concentration: 1mg/ml (OD280nm) (varies by lot)
• Sequence Length: 137

• Immunogen: Purified human IGF-1 conjugated to ovalbumin
• Affinity Constant: 108-10^9 l/mole
• Buffer: PBS
• Preservative: 0.09% Sodium azide
• Important Note: Centrifuge before opening to ensure complete recovery of vial contents.
• Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
• Preparation and Storage: Short-term (up to 1 month) store at 2 to 8 degree C. Long term, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.

Product Categories/Family for anti-IGF1 antibody

Monoclonal Antibodies to Cytokines and Growth Factors

References

• Morrell, D.J., et al., (1989), J. Mol. Endocrinal, 2, 201-206
• Maiorano, E., et al., (2000), Appl. Immunohistochem. Mol. Morphol. 8 (2).

NCBI and Uniprot Product Information

• NCBI GI #: 184834
• NCBI GeneID: 3479
• UniProt Accession #: Q14620; P05019; Q13429; Q59GC5; Q5U743; Q6LD41; Q9NP10
• Molecular Weight: 15,177 Da
• NCBI Official Full Name: insulin-like growth factor I
• NCBI Official Synonym Full Names: insulin-like growth factor 1 (somatomedin C)
• NCBI Official Symbol: IGF1
• NCBI Official Synonym Symbols: IGFI; IGF-I; IGF1A
• NCBI Protein Information: insulin-like growth factor 1; MGF; IGF-IA; IGF-IB; somatomedin-C; OTTHUMP00000195080; OTTHUMP00000195081; OTTHUMP00000195082; OTTHUMP00000195083; OTTHUMP00000195084; mechano growth factor; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB
• UniProt Protein Name: Insulin-like growth factor 1 (Somatomedin C), isoform CRA_c
• Protein Family: Insulin-like growth factor
• UniProt Gene Name: IGF1
• UniProt Entry Name: Q14620_HUMAN

NCBI Description

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.

Uniprot Description

IGF1: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency). IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. Belongs to the insulin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: insulin-like growth factor binding protein complex; extracellular space; plasma membrane; extracellular region

Molecular Function: integrin binding; insulin-like growth factor receptor binding; protein binding; growth factor activity; hormone activity; insulin receptor binding

Biological Process: muscle development; positive regulation of transcription, DNA-dependent; chondroitin sulfate proteoglycan biosynthetic process; glycolate metabolic process; exocrine pancreas development; water homeostasis; positive regulation of glucose import; positive regulation of fibroblast proliferation; proteoglycan biosynthetic process; inner ear development; positive regulation of DNA binding; muscle hypertrophy; platelet activation; positive regulation of protein import into nucleus, translocation; positive regulation of mitosis; regulation of establishment and/or maintenance of cell polarity; positive regulation of phosphoinositide 3-kinase cascade; cell activation; positive regulation of peptidyl-tyrosine phosphorylation; branching morphogenesis of a tube; insulin-like growth factor receptor signaling pathway; regulation of gene expression; response to heat; positive regulation of transcription from RNA polymerase II promoter; alveolus development; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of smooth muscle cell proliferation; myoblast proliferation; positive regulation of glycogen biosynthetic process; positive regulation of smooth muscle cell migration; positive regulation of activated T cell proliferation; signal transduction; negative regulation of cell proliferation; glial cell differentiation; platelet degranulation; positive regulation of MAPKKK cascade; mammary gland development; positive regulation of cell proliferation; DNA replication; skeletal development; positive regulation of granule cell precursor proliferation; phosphoinositide-mediated signaling; multicellular organism growth; regulation of multicellular organism growth; myotube cell development; satellite cell compartment self-renewal involved in skeletal muscle regeneration; myoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of protein kinase B signaling cascade; cell proliferation; cellular protein metabolic process; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of glycolysis; Ras protein signal transduction; blood vessel remodeling; positive regulation of Ras protein signal transduction; blood coagulation; cell motility; positive regulation of DNA replication

Disease: Insulin-like Growth Factor I Deficiency