Human anti-Human Infliximab Monoclonal Antibody
Infliximab, Chimeric Antibody
Reactivity
Human
Synonyms
Infliximab; Monoclonal Antibody; Chimeric Antibody; TA-650; cA2; TNF-alpha; anti-Infliximab antibody
Host
Human
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1-kappa
Form/Format
Liquid. Supplied as solution form in PBS pH 7.4.
Concentration
1mg/ml (varies by lot)
Antibody Type
Recombinant Antibody
Source
CHO cells
CAS Number
170277-31-3
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store at -80 degree C
Related Product Information for anti-Infliximab antibody
Infliximab is a humanized antibody against tumor necrosis factor alpha (TNF-alpha) that is used in the treatment of Crohn's disease and rheumatoid arthritis.Infliximab is a IgG1kappa monoclonal antibody that binds to soluble and transmembrane forms of TNF-alpha with high affinity to disrupt the pro-inflammatory cascade signalling.Binding of the antibody to TNF-alpha prevents TNF-alpha from interacting with its receptors.Infliximab does not neutralize TNF-beta (lymphotoxin-alpha), a related cytokine that utilizes the same receptors as TNF-alpha Label.Blocked actions of TNF-alpha further leads to downregulation of local and systemic pro-inflammatory cytokines (i.e. IL-1, IL-6), reduction of lymphocyte and leukocyte migration to sites of inflammation, induction of apoptosis of TNF-producing cells (i.e. activated monocytes and T lymphocytes), increased levels of nuclear factor-kappaB inhibitor, and reduction of reduction of endothelial adhesion molecules and acute phase proteins 3. Its inhibitory actions on TNF-alpha was demonstrated in human fibroblasts, endothelial cells, neutrophils, B and Tlymphocytes and epithelial cells Label.Infliximab also atteunates the production of tissue degrading enzymes synthesized by synoviocytes and/or chondrocytes. According to a transgenic mice study that developed polyarthritis due to consitutive levels of human TNF-alpha, infliximab decreased synovitis and joint erosions in collagen-induced arthritis and allows eroded joints to heal Label.
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Product Notes
The Infliximab (Catalog #AAA156130) is an Antibody produced from Human and is intended for research purposes only. The product is available for immediate purchase. The Infliximab, Chimeric Antibody reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Infliximab, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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