Mouse anti-Human ILT7 Monoclonal Antibody | anti-LILRA4 antibody

ILT7 (Leukocyte Immunoglobulin-like Receptor Subfamily A Member 4, CD85 Antigen-like Family Member G, Immunoglobulin-like Transcript 7, ILT-7, CD85g, LILRA4)

Cat. Num. AAA6001502

• Gene Names: LILRA4; ILT7; CD85g
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: ILT7; Monoclonal Antibody; ILT7 (Leukocyte Immunoglobulin-like Receptor Subfamily A Member 4; CD85 Antigen-like Family Member G; Immunoglobulin-like Transcript 7; ILT-7; CD85g; LILRA4); Anti -ILT7 (Leukocyte Immunoglobulin-like Receptor Subfamily A Member 4; anti-LILRA4 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, k
• Clone Number: 17G10.2
• Specificity: Recognizes human ILT7.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-LILRA4 antibody: Flow Cytometry (FC/FACS)
• Application Notes: Suitable for use in Flow Cytometry.; Dilution: Flow Cytometry: 0.5ug/10e6 cells in 100ul
• Immunogen: Human ILT7
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-LILRA4 antibody

ILT7 (immunoglobulin-like transcript 7) is a member of leukocyte immunoglobulin-like receptor (LIR or LILR) gene family, also known as CD85g and LILRA4. It contains four extracellular Ig domains. In association with FceR1y, ILT7 forms a receptor complex that transduces ITAM-mediated signals. ILT7 is specifically expressed on plasmacytoid dendritic cells (pDCs), but not on myeloid dendritic cells and other peripheral blood leukocytes. ILT7 negatively regulates the innate immune functions of human pDCs. Cross-linking I7502-77 antibody is able to trigger ILT7 mediated signaling.

Product Categories/Family for anti-LILRA4 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 4104891
• NCBI GeneID: 23547
• UniProt Accession #: P59901; Q32MC4
• Molecular Weight: 55,165 Da
• NCBI Official Full Name: immunoglobulin-like transcript 7
• NCBI Official Synonym Full Names: leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
• NCBI Official Symbol: LILRA4
• NCBI Official Synonym Symbols: ILT7; CD85g
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily A member 4; ILT-7; immunoglobulin-like transcript 7; CD85 antigen-like family member G; leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 4
• UniProt Protein Name: Leukocyte immunoglobulin-like receptor subfamily A member 4
• Protein Family: Leukocyte immunoglobulin-like receptor subfamily
• UniProt Gene Name: LILRA4
• UniProt Synonym Gene Names: ILT7; ILT-7
• UniProt Entry Name: LIRA4_HUMAN

NCBI Description

This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a leukocyte receptor gene cluster (LRC) at chromosomal region 19q13.4. [provided by RefSeq, Jul 2008]

Uniprot Description

LILRA4: May act as receptor for class I MHC antigens. Ligand binding leads to the activation of eosinophils and to the release of RNASE2, IL4 and leukotriene C4. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to membrane

Molecular Function: protein binding

Biological Process: immune system process