Western Blot (WB)
(Fig-1: Western blot analysis of IL-23R. Anti-IL-23R antibody (Clone: ABM25G4) was used at 1 ug/ml on (1) MCF-7, (2) THP1 and (3) A431 lysates.)
Mouse anti-Human IL-23R Monoclonal Antibody | anti-IL-23R antibody
Monoclonal Antibody to IL-23R (Clone: ABM25G4)
Reactivity
Human
Applications
Western Blot
Purity
PurifiedProtein G Chromatography
Synonyms
IL-23R; Monoclonal Antibody; Monoclonal Antibody to IL-23R (Clone: ABM25G4); Interleukin-23 receptor; IL-23 receptor; anti-IL-23R antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1, Kappa
Clone Number
ABM25G4
Purity/Purification
Purified
Protein G Chromatography
Protein G Chromatography
Form/Format
100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Sequence Length
629
Applicable Applications for anti-IL-23R antibody
Western Blot (WB)
Application Notes
WB: 1-2 ug/ml
Antigen
IL-23R
Immunogen Information
A partial length recombinant protein (a.a 250-450) of IL-23R was used as the immunogen for this antibody.
Conjugation
Unconjugated
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeat freezing and thawing
For long-term storage, store at -20 degree C.
Avoid repeat freezing and thawing
Western Blot (WB)
(Fig-1: Western blot analysis of IL-23R. Anti-IL-23R antibody (Clone: ABM25G4) was used at 1 ug/ml on (1) MCF-7, (2) THP1 and (3) A431 lysates.)
Western Blot (WB)
(Fig-1: Western blot analysis of IL-23R. Anti-IL-23R antibody (Clone: ABM25G4) was used at 1 ug/ml on (1) MCF-7, (2) THP1 and (3) A431 lysates.)
Related Product Information for anti-IL-23R antibody
IL-23, a member of the IL-12 cytokine family, is composed of a p40 subunit, which is shared with IL-12, and a p19 subunit, with an approximate molecular weight of 60 kDa. IL-23 is produced by activated dendritic cells and macrophages in response to microorganisms. IL-23 promotes Th17 cells producing TNF-a, IL-17, IL-6, IL-22, GM-CSF, and other novel factors, which are associated with the induction of autoimmune inflammation. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.
Product Categories/Family for anti-IL-23R antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
25,551 Da
NCBI Official Full Name
interleukin-23 receptor
NCBI Official Synonym Full Names
interleukin 23 receptor
NCBI Official Symbol
IL23R
NCBI Protein Information
interleukin-23 receptor
UniProt Protein Name
Interleukin-23 receptor
UniProt Gene Name
IL23R
UniProt Synonym Gene Names
IL-23 receptor; IL-23R
NCBI Description
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
Uniprot Description
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Research Articles on IL-23R
Similar Products
Product Notes
The IL-23R il23r (Catalog #AAA668975) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Monoclonal Antibody to IL-23R (Clone: ABM25G4) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IL-23R can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1-2 ug/ml. Researchers should empirically determine the suitability of the IL-23R il23r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-23R, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
