Mouse anti-Human IL-2 Monoclonal Antibody | anti-IL-2 antibody

Mouse Anti-Human IL-2

Cat. Num. AAA690756

• Gene Names: IL2; IL-2; TCGF; lymphokine
• Reactivity: Human
• Purity: Protein A chromatography
• Synonyms: IL-2; Monoclonal Antibody; Mouse Anti-Human IL-2; Monoclonal antibody anti-human IL-2; anti-IL-2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Purity/Purification: Protein A chromatography
• Form/Format: Lyophilized
• Sequence Length: 153

• Application Notes: ELISA: In a sandwich ELISA (assuming 100ul/well), a concentration of 2.0-4.0 ug/ml of this antibody will detect at least 1000 pg/ml of recombinant human IL-2 when used in conjunction with compatible secondary reagents.
• Antibody Generation: Produced in BALB/c mice using highly pure (>98%) recombinant human IL-2 as the immunizing antigen. This IgG1K antibody was purified from ascites fluid by Protein A affinity chromatography.
• Buffer: PBS

Related Product Information for anti-IL-2 antibody

Interleukin 2 (IL-2) was initially identified as a T cell growth factor that is produced by T cells following activation by mitogens or antigens. Since then, it has also been shown to stimulate the growth and differentiation of B cells, natural killer (NK) cells, lymphocyte activated killer (LAK) cells, monocytes/macrophages and oligodendrocytes. At the amino acid sequence level, there is approximately 60% - 90% similarity between species. Mature human IL-2 shows 65%, 67%, 72%, 78%, and 64% aa identity to mouse, rat, pig, cat, and cow IL-2, respectively.

NCBI and Uniprot Product Information

• NCBI GI #: 28178861
• NCBI GeneID: 3558
• NCBI Accession #: NP_000577.2
• NCBI GenBank Nucleotide #: NM_000586.3
• UniProt Accession #: P60568; P01585
• Molecular Weight: 17,628 Da
• NCBI Official Full Name: interleukin-2
• NCBI Official Synonym Full Names: interleukin 2
• NCBI Official Symbol: IL2
• NCBI Official Synonym Symbols: IL-2; TCGF; lymphokine
• NCBI Protein Information: interleukin-2; aldesleukin; T cell growth factor; involved in regulation of T-cell clonal expansion
• UniProt Protein Name: Interleukin-2
• UniProt Gene Name: IL2
• UniProt Synonym Gene Names: IL-2; TCGF
• UniProt Entry Name: IL2_HUMAN

NCBI Description

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Subcellular location: Secreted.

Involvement in disease: A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Pharmaceutical use: Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.

Sequence similarities: Belongs to the IL-2 family.

Sequence caution: The sequence AAA59140.1 differs from that shown. Reason: Erroneous initiation.