Rat anti-Mouse IL-12/IL-23 p40 Monoclonal Antibody | anti-IL-12/IL-23 antibody
PE Anti-Mouse IL-12/IL-23 p40 (C17.8)
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay
Purity
Affinity Purified
Synonyms
IL-12/IL-23 p40; Monoclonal Antibody; PE Anti-Mouse IL-12/IL-23 p40 (C17.8); anti-IL-12/IL-23 antibody
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Rat IgG2a, kappa
Clone Number
C17.8
Purity/Purification
Affinity Purified
Form/Format
Liquid. 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3,0.1% gelatin, pH7.2
Applicable Applications for anti-IL-12/IL-23 antibody
Flow Cytometry (FC/FACS)
Conjugation
PE-conjugated
Preparation and Storage
Shipping Condition: Ice Packs
Related Product Information for anti-IL-12/IL-23 antibody
The C17.8 antibody is specific for the 40kDa (p40) protein subunit shared by the cytokines IL-12 and IL-23. To form IL-12, p40 assembles with a separate 35kDa protein known as p35, resulting in a 70kDa functional cytokine. IL-12 is secreted by activated monocytes, macrophages, and dendritic cells, and has been shown to target nave, resting CD4 T cells to promote their proliferation and secretion of cytokines. IL-23 contains the p40 subunit in combination with a 19kDa protein chain, p19; its primary source being activated dendritic cells and other antigen-presenting cells. IL-23 appears to target different cell types than IL-12, acting on memory CD4 T cells to induce a strong proliferative response and contributing to the generation and expansion of Th17 cells. Like the cytokines themselves, the receptors for IL-12 and IL-23 share one subunit, as well as containing distinct cytokine-specific subunits.As the C17.8 antibody binds to a shared subunit of both IL-12 and IL-23, it may be used as a marker for either IL-12 or IL-23 expression in dendritic cells, monocytes and macrophages, and is widely used for neutralization of activity associated with either cytokine. Please choose the appropriate format for each application.
Product Categories/Family for anti-IL-12/IL-23 antibody
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Product Notes
The IL-12/IL-23 (Catalog #AAA4165515) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The PE Anti-Mouse IL-12/IL-23 p40 (C17.8) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's IL-12/IL-23 p40 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the IL-12/IL-23 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-12/IL-23 p40, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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