Mouse anti-Human IGFBP3/IBP-3 Monoclonal Antibody | anti-IGFBP3/IBP-3 antibody

Mouse anti Human IGFBP3/IBP-3 Monoclonal Antibody

Cat. Num. AAA2543382

• Gene Names: IGFBP3; IBP3; BP-53
• Reactivity: Human
• Applications: ELISA
• Synonyms: IGFBP3/IBP-3; Monoclonal Antibody; Mouse anti Human IGFBP3/IBP-3 Monoclonal Antibody; anti-IGFBP3/IBP-3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a
• Sequence Length: 297

• Applicable Applications for anti-IGFBP3/IBP-3 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.5-1 mug/mL. This antibody can be used at 0.5-1 mug/mL with the appropriate secondary reagents to detect IGFBP3. The detection limit for IGFBP3 is approximately 0.078 ng/well.
• Immunogen: Recombinant Human IGFBP3 protein
• Buffer: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IGFBP3 (rh IGFBP3; NP_000589.2; Gly 28-Lys 291). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 62243248
• NCBI GeneID: 3486
• NCBI GenBank Nucleotide #: NM_001013398.1
• Molecular Weight: 32,223 Da
• NCBI Official Full Name: insulin-like growth factor-binding protein 3 isoform a
• NCBI Official Synonym Full Names: insulin like growth factor binding protein 3
• NCBI Official Symbol: IGFBP3
• NCBI Official Synonym Symbols: IBP3; BP-53
• NCBI Protein Information: insulin-like growth factor-binding protein 3
• UniProt Protein Name: Insulin-like growth factor-binding protein 3
• UniProt Gene Name: IGFBP3
• UniProt Synonym Gene Names: IBP3; IBP-3; IGF-binding protein 3; IGFBP-3
• UniProt Entry Name: IBP3_HUMAN

NCBI Description

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.