Mouse anti-Human HP / Haptoglobin Monoclonal Antibody | anti-HP antibody

Mouse Monoclonal [clone 26E11] (IgG1,k) to Human HP / Haptoglobin

Cat. Num. AAA245547

• Gene Names: HP; BP; HPA1S; HP2ALPHA2
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Ammonium sulfate precipitation
• Synonyms: HP / Haptoglobin; Monoclonal Antibody; Mouse Monoclonal [clone 26E11] (IgG1; k) to Human HP / Haptoglobin; Anti-HP / Haptoglobin Antibody (clone 26E11) IHC-plus; HP; Binding peptide; Haptoglobin alpha(1S)-beta; Haptoglobin; beta polypeptide; Haptoglobin alpha(2FS)-beta; alpha polypeptide; HP2ALPHA2; BP; Zonulin; HPA1S; Human HP; anti-HP antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 26E11
• Purity/Purification: Ammonium sulfate precipitation
• Form/Format: HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Sourced in Ascites.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 406

• Applicable Applications for anti-HP antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, IHC-P (1:200), WB (1:500)
• Target: HP/Haptoglobin
• Target Species: Human
• Immunogen Description: Protein purified from Human plasma.
• Immunogen: HP/Haptoglobin antibody was raised against protein purified from Human plasma.
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC)

(Anti-Haptoglobin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.)

Western Blot (WB)

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Related Product Information for anti-HP antibody

HP / Haptoglobin is a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 4826762
• NCBI GeneID: 3240
• NCBI Accession #: NP_005134.1
• NCBI GenBank Nucleotide #: NM_005143.3
• UniProt Accession #: P00738; P00737; Q0VAC4; Q0VAC5; Q2PP15; Q3B7J0; Q6LBY9; Q9UC67; B0AZL5
• Molecular Weight: 38,452 Da
• NCBI Official Full Name: haptoglobin isoform 1 preproprotein
• NCBI Official Synonym Full Names: haptoglobin
• NCBI Official Symbol: HP
• NCBI Official Synonym Symbols: BP; HPA1S; HP2ALPHA2
• NCBI Protein Information: haptoglobin; zonulin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, beta polypeptide; haptoglobin, alpha polypeptide
• UniProt Protein Name: Haptoglobin
• UniProt Gene Name: HP
• UniProt Entry Name: HPT_HUMAN

NCBI Description

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

Uniprot Description

HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16q22.2

Cellular Component: extracellular space; extracellular region

Molecular Function: antioxidant activity; protein binding; hemoglobin binding; catalytic activity

Biological Process: receptor-mediated endocytosis; response to hydrogen peroxide; immune system process; metabolic process; negative regulation of oxidoreductase activity; defense response to bacterium; acute-phase response; defense response

Disease: Anhaptoglobinemia