Mouse anti-Human HEXIM1 Monoclonal Antibody | anti-HEXIM1 antibody

Anti-HEXIM1 Antibody (clone 2D12)

Cat. Num. AAA2401039

• Gene Names: HEXIM1; CLP1; EDG1; HIS1; MAQ1
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Purified from ascites by Protein A
• Synonyms: HEXIM1; Monoclonal Antibody; Anti-HEXIM1 Antibody (clone 2D12); Goat Polyclonal to Human HEXIM1; Cardiac lineage protein 1; CLP-1; EDG1; HMBA-inducible; Menage a quatre 1; Menage a quatre protein 1; Protein HEXIM1; MAQ1; HIS1; anti-HEXIM1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a, k
• Clone Number: 2D12
• Specificity: Human HEXIM1
• Purity/Purification: Purified from ascites by Protein A
• Form/Format: PBS, pH 7.4.
• Sequence Length: 359

• Applicable Applications for anti-HEXIM1 antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin
• Application Notes: IHC-P: 3-10 ug/ml
• Immunogen: HEXIM1 (AAH06460, 1 a.a. ~ 360 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C or lower.; Aliquot to avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-HEXIM1 antibody IHC staining of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

ELISA (EIA)

(Detection limit for recombinant GST tagged HEXIM1 is 0.1 ng/ml as a capture antibody.)

Related Product Information for anti-HEXIM1 antibody

Transcriptional regulator which functions as a general RNA polymeraseII transcription inhibitor. In cooperation with 7SK snRNA sequestersP-TEFb in a large inactive 7SK snRNP complex preventing RNA polymeraseII phosphorylation and subsequent transcriptional elongation. May alsoregulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptionalactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 5453682
• NCBI GeneID: 10614
• NCBI Accession #: NP_006451.1
• NCBI GenBank Nucleotide #: NM_006460.2
• UniProt Accession #: O94992; B2R8Y5
• Molecular Weight: 40,623 Da
• NCBI Official Full Name: protein HEXIM1
• NCBI Official Synonym Full Names: hexamethylene bisacetamide inducible 1
• NCBI Official Symbol: HEXIM1
• NCBI Official Synonym Symbols: CLP1; EDG1; HIS1; MAQ1
• NCBI Protein Information: protein HEXIM1
• UniProt Protein Name: Protein HEXIM1
• Protein Family: Protein
• UniProt Gene Name: HEXIM1
• UniProt Synonym Gene Names: CLP1; EDG1; HIS1; MAQ1

NCBI Description

Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]

Uniprot Description

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).