Mouse Hemoglobin epsilon Monoclonal Antibody | anti-HBE1 antibody

Hemoglobin epsilon antibody (FITC)

Cat. Num. AAA532515

• Gene Names: HBE1; HBE
• Applications: ELISA
• Synonyms: Hemoglobin epsilon; Monoclonal Antibody; Hemoglobin epsilon antibody (FITC); Monoclonal Hemoglobin epsilon; Anti-Hemoglobin epsilon; Hemoglobin; anti-HBE1 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1 kappa
• Clone Number: 90050
• Specificity: Hemoglobin epsilon
• Form/Format: PBS, pH 7.4, 10mM NaN3.
• Concentration: 1.0 mg/ml (by UV absorbance at 280nm) (varies by lot)
• Sequence Length: 147

• Applicable Applications for anti-HBE1 antibody: ELISA (EIA)
• Application Notes: ELISA: 1:100,000
• Biological Significance: Hemoglobin Gower-1 is found as a minor Hb in the early embryo. It disappears by the third month of pregnancy in favour of haemoglobin Gower-2 and haemaglobin Portland and then Hb F. The zeta chain has 141 amino acid residues. Synthesis of the zeta chain is deficient in cases of hydrops foetalis.
• Cross-Reactivity: Hb Gamma chain < 0.01%, Hb Beta chain < 0.01%, Hb Delta chain < 0.01%
• Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
• Tag/Conjugate: FITC
• Immunogen: Hemoglobin epsilon antibody (FITC) was raised in mouse using hemoglobin gower-I (alpha2 epsilon2) isolated from culture fluids of the cell line K562 as the immunogen.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-HBE1 antibody

Mouse monoclonal Hemoglobin epsilon antibody (FITC)

Product Categories/Family for anti-HBE1 antibody

Nutrition & Metabolism; Conjugated Monoclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 4885393
• NCBI GeneID: 3046
• NCBI Accession #: NP_005321.1
• NCBI GenBank Nucleotide #: NM_005330.3
• UniProt Accession #: P02100; Q6FH44
• Molecular Weight: 16,203 Da
• NCBI Official Full Name: hemoglobin subunit epsilon
• NCBI Official Synonym Full Names: hemoglobin, epsilon 1
• NCBI Official Symbol: HBE1
• NCBI Official Synonym Symbols: HBE
• NCBI Protein Information: hemoglobin subunit epsilon
• UniProt Protein Name: Hemoglobin subunit epsilon
• Protein Family: Hemoglobin
• UniProt Gene Name: HBE1
• UniProt Synonym Gene Names: HBE
• UniProt Entry Name: HBE_HUMAN

NCBI Description

The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3' [provided by RefSeq, Jul 2008]

Uniprot Description

HBE1: The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin. Belongs to the globin family.

Protein type: Carrier

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: hemoglobin complex; cytosol

Molecular Function: iron ion binding; heme binding; hemoglobin alpha binding; oxygen binding; oxygen transporter activity

Biological Process: protein heterooligomerization; oxygen transport; negative regulation of transcription from RNA polymerase II promoter; blood coagulation