Western Blot (WB)
(Western blot detection of HDAC4 in Jurkat, Hela and K562 cell lysates using HDAC4 mouse mAb (1:1000 diluted).Predicted band size: 140KDa.Observed band size: 140KDa.)
anti-Human HDAC4 Monoclonal Antibody | anti-HDAC4 antibody
Anti-HDAC4 (N-term) Mouse mAb
Source: Human
Western Blot (WB)
(Western blot detection of HDAC4 in Jurkat, Hela and K562 cell lysates using HDAC4 mouse mAb (1:1000 diluted).Predicted band size: 140KDa.Observed band size: 140KDa.)
Western Blot (WB)
(Western blot detection of HDAC4 in Jurkat, Hela and K562 cell lysates using HDAC4 mouse mAb (1:1000 diluted).Predicted band size: 140KDa.Observed band size: 140KDa.)
Immunoprecipitation (IP)
(Immunoprecipitation analysis of Hela cell lysates using HDAC4 mouse mAb.)
Immunoprecipitation (IP)
(Immunoprecipitation analysis of Hela cell lysates using HDAC4 mouse mAb.)
Western Blot (WB)
(Western blot detection of HDAC4 in C2C12, 3T3, K562, Jurkat and Hela cell lysates using HDAC4 mouse mAb (dilution 1:1000).Predicted band size:140kDa.Observed band size:140kDa.)
Western Blot (WB)
(Western blot detection of HDAC4 in C2C12, 3T3, K562, Jurkat and Hela cell lysates using HDAC4 mouse mAb (dilution 1:1000).Predicted band size:140kDa.Observed band size:140kDa.)
NCBI and Uniprot Product Information
NCBI Description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Uniprot Description
HDAC4: a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Protein type: Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: cytoplasm; histone deacetylase complex; nucleoplasm; nucleus; transcriptional repressor complex
Molecular Function: histone deacetylase activity; histone deacetylase binding; potassium ion binding; protein binding; protein deacetylase activity; sequence-specific DNA binding; transcription activator binding; transcription factor binding; zinc ion binding
Biological Process: B cell activation; B cell differentiation; cardiac muscle hypertrophy; chromatin remodeling; histone deacetylation; inflammatory response; negative regulation of glycolysis; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nervous system development; positive regulation of cell proliferation; positive regulation of protein sumoylation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of gene expression, epigenetic; regulation of protein binding; response to denervation involved in regulation of muscle adaptation
Research Articles on HDAC4
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Product Notes
The HDAC4 hdac4 (Catalog #AAA475081) is an Antibody produced from Mouse Source: Human and is intended for research purposes only. The product is available for immediate purchase. The Anti-HDAC4 (N-term) Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HDAC4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP). WB: 1:1000. Researchers should empirically determine the suitability of the HDAC4 hdac4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HDAC4, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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