Immunohistochemistry (IHC)
(Anti-HCN1 antibody IHC of human pancreas, islets of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.)
Mouse HCN1 Monoclonal Antibody | anti-HCN1 antibody
Mouse Monoclonal [clone S70-28] (IgG1) to Rat HCN1
Usage: Western Blot: Use the lysate in SDS buffer but without boiling, incubating for 20 mins at 37 degree C instead.
Immunohistochemistry (IHC)
(Anti-HCN1 antibody IHC of human pancreas, islets of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.)
Immunohistochemistry (IHC)
(Anti-HCN1 antibody IHC of human pancreas, islets of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.)
Immunohistochemistry (IHC)
(IHC analysis of HCN1 in frozen sections of mouse brain extract using HCN1 antibody.)
Immunohistochemistry (IHC)
(IHC analysis of HCN1 in frozen sections of mouse brain extract using HCN1 antibody.)
Immunofluorescence (IF)
(HCN1 (S70-28), Human Hippocampus.)
Immunofluorescence (IF)
(HCN1 (S70-28), Human Hippocampus.)
Western Blot (WB)
(Western blot analysis of HCN1 in rat brain membrane lysates using a 1:1000 dilution of HCN1 antibody.)
Western Blot (WB)
(Western blot analysis of HCN1 in rat brain membrane lysates using a 1:1000 dilution of HCN1 antibody.)
NCBI and Uniprot Product Information
NCBI Description
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]
Uniprot Description
HCN1: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli. Belongs to the potassium channel HCN family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5p12
Cellular Component: integral to plasma membrane; axon; dendrite; plasma membrane; integral to membrane
Molecular Function: identical protein binding; voltage-gated potassium channel activity; potassium channel activity; intracellular cAMP activated cation channel activity; voltage-gated sodium channel activity; cAMP binding
Biological Process: synaptic transmission; apical protein localization; regulation of membrane potential; retinal cone cell development; potassium ion transport
Disease: Epileptic Encephalopathy, Early Infantile, 24
Research Articles on HCN1
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Product Notes
The HCN1 hcn1 (Catalog #AAA246184) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Monoclonal [clone S70-28] (IgG1) to Rat HCN1 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HCN1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB), Immunoprecipitation (IP). ICC (0.1 - 1 ug/ml), IHC-P (1:50), IP (1 - 10 ug/ml), WB (1 - 10 ug/ml) Usage: Western Blot: Use the lysate in SDS buffer but without boiling, incubating for 20 mins at 37 degree C instead. Researchers should empirically determine the suitability of the HCN1 hcn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HCN1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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