Mouse HAGH Monoclonal Antibody | anti-HAGH antibody
HAGH (Hydroxyacylglutathione Hydrolase, GLO2, GLX2, GLXII, HAGH1) (APC)
NCBI and Uniprot Product Information
NCBI Description
The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Uniprot Description
HAGH: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; EC 3.1.2.6; Carbohydrate Metabolism - pyruvate; Hydrolase
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: mitochondrial matrix; cytoplasm
Molecular Function: hydroxyacylglutathione hydrolase activity; zinc ion binding
Biological Process: glutathione biosynthetic process
Disease: Hydroxyacyl Glutathione Hydrolase Deficiency