Mouse anti-Human GOSR2/Membrin Monoclonal Antibody | anti-GOSR2 antibody

GOSR2/Membrin Mouse Monoclonal

Cat. Num. AAA769798

• Gene Names: GOSR2; Bos1; EPM6; GS27
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Protein A+G purification
• Synonyms: GOSR2/Membrin; Monoclonal Antibody; GOSR2/Membrin Mouse Monoclonal; anti-GOSR2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a
• Purity/Purification: >=95% as determined by SDS-PAGE; Protein A+G purification
• Form/Format: Liquid
• Sequence Length: 195

• Applicable Applications for anti-GOSR2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Golgi SNAP receptor complex member 2
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver slide using MBS769798 (GOSR2 Antibody) at dilution of 1:50)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS769798 (GOSR2 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 60499013
• NCBI GeneID: 9570
• NCBI Accession #: NP_001012529.1
• NCBI GenBank Nucleotide #: NM_001012511.2
• Molecular Weight: 22,725 Da
• NCBI Official Full Name: Golgi SNAP receptor complex member 2 isoform C
• NCBI Official Synonym Full Names: golgi SNAP receptor complex member 2
• NCBI Official Symbol: GOSR2
• NCBI Official Synonym Symbols: Bos1; EPM6; GS27
• NCBI Protein Information: Golgi SNAP receptor complex member 2
• UniProt Protein Name: Golgi SNAP receptor complex member 2
• Protein Family: Golgi SNAP receptor complex
• UniProt Gene Name: GOSR2
• UniProt Synonym Gene Names: GS27
• UniProt Entry Name: GOSR2_HUMAN

NCBI Description

This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. [provided by RefSeq, Mar 2016]

Uniprot Description

GOSR2: Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network. Defects in GOSR2 are the cause of progressive myoclonic epilepsy type 6 (EPM6). A neurologic disorder characterized by onset of ataxia in the first years of life, followed by action myoclonus and seizures later in childhood, and loss of independent ambulation in the second decade. Cognition is not usually affected, although mild memory difficulties may occur in the third decade. Belongs to the GOSR2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cytosol; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; Golgi apparatus; Golgi membrane; integral to membrane; late endosome membrane; membrane; SNARE complex

Molecular Function: protein binding; SNAP receptor activity; SNARE binding; transporter activity

Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; Golgi to vacuole transport; intra-Golgi vesicle-mediated transport; protein targeting to vacuole; retrograde transport, endosome to Golgi; vesicle fusion with Golgi apparatus

Disease: Epilepsy, Progressive Myoclonic 6