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Mouse Gonadotropin Releasing Hormone Monoclonal Antibody | anti-GNRH1 antibody

Gonadotropin Releasing Hormone Monoclonal Antibody

Gene Names
GNRH1; GRH; GNRH; LHRH; LNRH
Applications
ELISA, Immunohistochemistry
Synonyms
Gonadotropin Releasing Hormone; Monoclonal Antibody; Gonadotropin Releasing Hormone Monoclonal Antibody; Anti-Gonadotropin Releasing Hormone; GnRH; anti-GNRH1 antibody
Ordering
For Research Use Only!
Host
Mouse
Clonality
Monoclonal
Isotype
IgG1
Specificity
Anti-Gonadotropin Releasing Hormone [Murine MAbs recognize human gonadotropin releasing hormone (4 clones). LP]
Form/Format
1 ml ascites or 1 mg Protein G-purified antibody in PBS, pH 7.4.
Sequence Length
92
Applicable Applications for anti-GNRH1 antibody
ELISA, Immunohistochemistry
Application Notes
These antibodies may be used in ELISA, immunohistochemistry and RIA to detect and quantitate GnRH.
Antigen
Purified human gonadotropin releasing hormone.
Activity
Ig mg/ml*: 16.4
ELISA Titer**: 1: 25,600
ng GnRH for 50% Displacement: 8.85
(Note: * Determined by radial immunodiffusion for several lots of ascites.
**ELISA is an indirect assay against human GnRH on the solid phase. Titers represent endpoint dilutions that achieve absorbance values >= 0.1.)
Stabilizer
None.
Preservatives
None. Available on request.
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
These antibodies are stable for at least one (1) year at -20 degree to-70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Product Categories/Family for anti-GNRH1 antibody
References
Rajendren G and Gibson MJ (2001) J Neuroendocrinology 13: 270-274.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
10,380 Da
NCBI Official Full Name
gonadotropin-releasing hormone
NCBI Official Synonym Full Names
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
NCBI Official Symbol
GNRH1
NCBI Official Synonym Symbols
GRH; GNRH; LHRH; LNRH
NCBI Protein Information
progonadoliberin-1; luliberin I; OTTHUMP00000225172; OTTHUMP00000225173; progonadoliberin I; GnRH-associated peptide 1; prolactin release-inhibiting factor; gonadotropin-releasing hormone 1 (leutinizing-releasing hormone)
UniProt Protein Name
Progonadoliberin-1
Protein Family
UniProt Gene Name
GNRH1
UniProt Synonym Gene Names
GNRH; GRH; LHRH
UniProt Entry Name
GON1_HUMAN

NCBI Description

The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH), also known as gonadoliberin-1, and prolactin release-inhibiting factor, also known as GnRH-associated peptide 1. LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

Uniprot Description

GNRH1: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. Belongs to the GnRH family.

Protein type: Secreted, signal peptide; Cell cycle regulation; Hormone; Secreted

Chromosomal Location of Human Ortholog: 8p21-p11.2

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity; luteinizing hormone-releasing factor activity

Biological Process: negative regulation of cell proliferation; ovulation cycle; response to ethanol; cell-cell signaling; regulation of gene expression; multicellular organismal development; female pregnancy; signal transduction; response to corticosteroid stimulus; negative regulation of apoptosis

Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia

Research Articles on GNRH1

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Product Notes

The GNRH1 gnrh1 (Catalog #AAA190177) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Gonadotropin Releasing Hormone can be used in a range of immunoassay formats including, but not limited to, ELISA, Immunohistochemistry. These antibodies may be used in ELISA, immunohistochemistry and RIA to detect and quantitate GnRH. Researchers should empirically determine the suitability of the GNRH1 gnrh1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Gonadotropin Releasing Hormone, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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