Immunohistochemistry (IHC)
(Immunohistochemical staining of human ganglioblastoma with MBS604889 (1:50). Tissue is pretreated with Tris-EDTA buffer, pH 8.0, using high heat epitope retrieval techniques. Immunoreactivity is seen as cytoplasmic staining of the tumor cells with no staining detected in normal, uninvolved cells.)
Mouse anti-Human, Rat Glypican 1 Monoclonal Antibody | anti-GPC1 antibody
Glypican 1 (Glypiated Proteoglycan 1) (MaxLight 650)
Immunohistochemistry (IHC)
(Immunohistochemical staining of human ganglioblastoma with MBS604889 (1:50). Tissue is pretreated with Tris-EDTA buffer, pH 8.0, using high heat epitope retrieval techniques. Immunoreactivity is seen as cytoplasmic staining of the tumor cells with no staining detected in normal, uninvolved cells.)
Immunohistochemistry (IHC)
(Immunohistochemical staining of human ganglioblastoma with MBS604889 (1:50). Tissue is pretreated with Tris-EDTA buffer, pH 8.0, using high heat epitope retrieval techniques. Immunoreactivity is seen as cytoplasmic staining of the tumor cells with no staining detected in normal, uninvolved cells.)
Testing Data
(PC-12 cell lysate was probed with MBS604889 (0.5ug/ml) Proteins were visualized using an IgG (HRP) goat anti-mouse secondary antibody and chemiluminescence detection. Arrow indicates ~59kD.)
Testing Data
(PC-12 cell lysate was probed with MBS604889 (0.5ug/ml) Proteins were visualized using an IgG (HRP) goat anti-mouse secondary antibody and chemiluminescence detection. Arrow indicates ~59kD.)
NCBI and Uniprot Product Information
Uniprot Description
GPC1: Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Associates (via the heparan sulfate side chains) with fibrillar APP-beta amyloid peptides in primitive and classic amyloid plaques and may be involved in the deposition of these senile plaques in the Alzheimer disease (AD) brain. Misprocessing of GPC1 is found in fibroblasts of patients with Niemann-Pick Type C1 disease. This is due to the defective deaminative degradation of heparan sulfate chains. Belongs to the glypican family.
Protein type: Extracellular matrix; Membrane protein, GPI anchor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q35-q37
Cellular Component: lysosomal lumen; proteinaceous extracellular matrix; extracellular space; integral to plasma membrane; Golgi lumen; plasma membrane; endosome; lipid raft
Molecular Function: heparan sulfate proteoglycan binding; fibroblast growth factor binding; copper ion binding; laminin binding
Biological Process: axon guidance; phototransduction, visible light; heparan sulfate proteoglycan catabolic process; glycosaminoglycan metabolic process; negative regulation of fibroblast growth factor receptor signaling pathway; pathogenesis; Schwann cell differentiation; chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; myelin formation; glycosaminoglycan catabolic process; carbohydrate metabolic process; retinoid metabolic process
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Product Notes
The GPC1 gpc1 (Catalog #AAA6246717) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Glypican 1 (Glypiated Proteoglycan 1) (MaxLight 650) reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Glypican 1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the GPC1 gpc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Glypican 1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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