Mouse GluR2 Monoclonal Antibody | anti-GluR2 antibody
GluR2 (Glutamate Receptor) (AP)
NCBI and Uniprot Product Information
NCBI Description
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
GluR2: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated; Channel, calcium
Cellular Component: dendrite cytoplasm; cell surface; integral to plasma membrane; dendrite; integral to membrane; terminal button; postsynaptic membrane; synaptic vesicle; cell soma; membrane; synapse; dendritic shaft; endoplasmic reticulum membrane; neuron projection; protein complex; synaptic vesicle membrane; endoplasmic reticulum; postsynaptic density; dendritic spine; perikaryon; presynaptic membrane; asymmetric synapse; growth cone; ionotropic glutamate receptor complex; cell junction
Molecular Function: identical protein binding; protein binding; kainate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; calcium channel regulator activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; receptor activity; protein kinase binding; PDZ domain binding
Biological Process: synaptic transmission; establishment of protein localization; regulation of synaptic transmission, glutamatergic; ionotropic glutamate receptor signaling pathway; response to lithium ion; receptor internalization; regulation of receptor recycling; positive regulation of synaptic transmission; protein tetramerization
Research Articles on GluR2
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Product Notes
The GluR2 gria2 (Catalog #AAA6241686) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The GluR2 (Glutamate Receptor) (AP) reacts with Canine, Macaque, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GluR2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Radioimmunoassay (RIA), Western Blot (WB). Researchers should empirically determine the suitability of the GluR2 gria2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GluR2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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