Testing Data
(Figure 1. Expi 293 cell line transfected with irrelevant protein (A) and human GITR-L (B) were surface stained with Rabbit anti-GITR-L monoclonal antibody 15ug/ml (clone: DM52) followed by Alexa 488-conjugated anti-rabbit IgG secondary antibody.)
Rabbit anti-Human GITR-L Monoclonal Antibody | anti-GITR-L antibody
Anti-GITR-L antibody (DM52), Rabbit mAb
FC/FACS: 1:101
Testing Data
(Figure 1. Expi 293 cell line transfected with irrelevant protein (A) and human GITR-L (B) were surface stained with Rabbit anti-GITR-L monoclonal antibody 15ug/ml (clone: DM52) followed by Alexa 488-conjugated anti-rabbit IgG secondary antibody.)
Testing Data
(Figure 1. Expi 293 cell line transfected with irrelevant protein (A) and human GITR-L (B) were surface stained with Rabbit anti-GITR-L monoclonal antibody 15ug/ml (clone: DM52) followed by Alexa 488-conjugated anti-rabbit IgG secondary antibody.)
Flow Cytometry (FC/FACS)
(Figure 2. Flow cytometry data of serially titrated Rabbit anti-GITR-L monoclonal antibody (clone: DM52) on H929 cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.)
Flow Cytometry (FC/FACS)
(Figure 2. Flow cytometry data of serially titrated Rabbit anti-GITR-L monoclonal antibody (clone: DM52) on H929 cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]
Uniprot Description
TNFSF18: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Belongs to the tumor necrosis factor family.
Protein type: Membrane protein, integral; Apoptosis; Cytokine
Chromosomal Location of Human Ortholog: 1q23
Cellular Component: extracellular space; cell surface; plasma membrane; integral to membrane
Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; receptor binding
Biological Process: tumor necrosis factor-mediated signaling pathway; cell-cell signaling; T cell proliferation during immune response; regulation of T cell proliferation; signal transduction; negative regulation of apoptosis; activation of NF-kappaB transcription factor
Research Articles on GITR-L
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Product Notes
The GITR-L tnfsf18 (Catalog #AAA188187) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-GITR-L antibody (DM52), Rabbit mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GITR-L can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Flow Cytometry (FC/FACS). ELISA: 1:5000-10,000 FC/FACS: 1:101. Researchers should empirically determine the suitability of the GITR-L tnfsf18 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GITR-L, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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