Rabbit anti-Human GBA3/CBGL1  Monoclonal Antibody | anti-GBA3/CBGL1  antibody

Rabbit anti Human GBA3/CBGL1  Monoclonal Antibody

Cat. Num. AAA2544254

• Gene Names: GBA3; CBG; GLUC; KLRP; CBGL1
• Reactivity: Human
• Applications: ELISA
• Synonyms: GBA3/CBGL1 ; Monoclonal Antibody; Rabbit anti Human GBA3/CBGL1 Monoclonal Antibody; anti-GBA3/CBGL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 162

• Applicable Applications for anti-GBA3/CBGL1 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human GBA3. The detection limit for Human GBA3 is approximately 0. 31 ng/well.
• Immunogen: Recombinant Human GBA3 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 81097639
• NCBI GeneID: 57733
• Molecular Weight: 18,265 Da
• NCBI Official Full Name: GBA3 protein
• NCBI Official Synonym Full Names: glucosylceramidase beta 3 (gene/pseudogene)
• NCBI Official Symbol: GBA3
• NCBI Official Synonym Symbols: CBG; GLUC; KLRP; CBGL1
• NCBI Protein Information: cytosolic beta-glucosidase
• UniProt Protein Name: Cytosolic beta-glucosidase
• UniProt Gene Name: GBA3
• UniProt Synonym Gene Names: CBG; CBGL1
• UniProt Entry Name: GBA3_HUMAN

NCBI Description

The protein encoded by this gene is an enzyme that can hydrolyze several types of glycosides. This gene is a polymorphic pseudogene, with the most common allele being the functional allele that encodes the full-length protein. Some individuals, as represented by the reference genome allele, contain a single nucleotide polymorphism that results in a premature stop codon in the coding region, and therefore this allele is pseudogenic due to the failure to produce a functional full-length protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Uniprot Description

GBA3: Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta- glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - starch and sucrose; EC 3.2.1.21; Hydrolase; Other Amino Acids Metabolism - cyanoamino acid

Chromosomal Location of Human Ortholog: 4p15.2

Cellular Component: cytosol

Molecular Function: beta-galactosidase activity; beta-glucosidase activity; glucosylceramidase activity; glycosylceramidase activity

Biological Process: glycoside catabolic process; glycosphingolipid metabolic process; glycosylceramide catabolic process