Mouse Galectin-2 Monoclonal Antibody | anti-LGALS2 antibody

Galectin-2, Human, mAb 1H6-G6

Cat. Num. AAA584692

• Gene Names: LGALS2; HL14
• Reactivity: Reactivity: Human. Cross reactivity: Mouse
• Applications: Immuno Assay (IA)
• Synonyms: Galectin-2; Monoclonal Antibody; Human; mAb 1H6-G6; mAb 1H6; Beta-galactoside-binding lectin L-14-II; HL14; Lactose-binding lectin 2; S-Lac lectin 2; anti-LGALS2 antibody

• Host: Mouse
• Reactivity: Reactivity: Human. Cross reactivity: Mouse
• Clonality: Monoclonal
• Isotype: Mouse IgG1
• Clone Number: 1H6-G6
• Form/Format: 1 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide; For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)
• Sequence Length: 132

• Applicable Applications for anti-LGALS2 antibody: Immuno Assay (IA)
• Application Notes: For Immuno Assays, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
• Immunogen: Recombinant human galectin-2
• Preparation and Storage: Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label

Related Product Information for anti-LGALS2 antibody

The monoclonal antibody 1H6 reacts with galectin-2. Galectins are beta-galactoside-binding lectins. They have a characteristic carbohydrate recognition domain (CRD) and are widely expressed in a wide range of organisms. Galectins are involved in the regulation of cell proliferation, inflammation, cell adhesion and cell death. Based on structural features, mammalian galectins have been classified as proto, chimera or tandem repeats. Galectin-2 is of the proto type. Proto types contain one CRD per subunit and are usually homodimers of non-covalently linked subunits. Although galectins lack a typical secretion signal peptide, they are present not only in the cytosol and the nucleus, but also in the extracellular space. During the infection process, galectins have diverse effects on cells involved in innate immune responses, including macrophages, dendritic cells, neutrophils and mast cells. For example many host-microorganism interactions have been shown to involve protein-carbohydrate recognition. Thereby facilitating the interaction with colonizing microorganism, or initiate innate and adaptive immune responses against the pathogen. Galectin-2 is structurally related to galectins-1 (43% sequence identity to gal-1), but is primarily expressed in the gastrointestinal tract and induces apoptosis in activated T-cells. Human and mouse gal-2 share ca 65% amino acid sequence similarity. The exact function of gal-2 remains unclear until now. Interaction studies showed binding of gal-2, present in macrophages and smooth muscle cells, to lymphotoxin-alpha and also alpha-and beta-tubulins, implicating involvement in regulation of cytokine secretion relevant for the pathogenesis of myocardial infarction. Furthermore, Gal-2 has proven growth-regulatory activity, is reactive with apoptotic cells, and has the potential to modulate cell adhesion