Rabbit GABA A alpha 5 Monoclonal Antibody | anti-GABRA5 antibody

GABA A Receptor alpha 5 Conjugated Antibody

Cat. Num. AAA9457376

• Reactivity: Human, Mouse, Rat
• Applications: Most Applications
• Synonyms: GABA A alpha 5; Monoclonal Antibody; GABA A Receptor alpha 5 Conjugated Antibody; GAA 5 antibody; GAA5 antibody; GABA (A) receptor subunit alpha-5 antibody; GABRA 5 antibody; Gabra5 antibody; Gamma aminobutyric acid GABA A receptor alpha 5 antibody; Gamma aminobutyric acid GABA A receptor alpha 5 precursor antibody; Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor antibody; Gamma-aminobutyric acid receptor subunit alpha-5 antibody; GBRA5_HUMAN antibody; GC138184 antibody; anti-GABRA5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

• Applicable Applications for anti-GABRA5 antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant protein
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

Related Product Information for anti-GABRA5 antibody

GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Ralpha1-6, GABAA R beta 1-3, GABAA Rgamma1-3, GABAA Rdelta , GABAA Repsilon, GABAA Rï1 and GABAA Rï2. The GABAB family is composed of GABAB R1alpha and GABAB R1beta . GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.

NCBI and Uniprot Product Information

• NCBI GI #: 259013560
• NCBI GeneID: 2558
• NCBI Accession #: NP_001158509.1
• NCBI GenBank Nucleotide #: NM_001165037.1
• UniProt Accession #: P31644; Q14DC2; Q53XL6; Q9NYT3; Q9NYT4; Q9NYT5; A8K338; AAB22608
• Molecular Weight: 52,146 Da
• NCBI Official Full Name: gamma-aminobutyric acid receptor subunit alpha-5
• NCBI Official Synonym Full Names: gamma-aminobutyric acid (GABA) A receptor, alpha 5
• NCBI Official Symbol: GABRA5
• NCBI Protein Information: gamma-aminobutyric acid receptor subunit alpha-5; GABA(A) receptor subunit alpha-5
• UniProt Protein Name: Gamma-aminobutyric acid receptor subunit alpha-5
• Protein Family: Gamma-aminobutyric acid receptor
• UniProt Gene Name: GABRA5
• UniProt Entry Name: GBRA5_HUMAN

NCBI Description

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Subcellular location: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub-subfamily. [View classification]