Western Blot (WB)
(Western Blot analysis of MCF-7 cells using FRS2 Monoclonal Antibody at dilution of 1:1000)
Mouse anti-Human FRS2 Monoclonal Antibody | anti-FRS2 antibody
FRS2 Monoclonal Antibody
Gene Names
FRS2; SNT; SNT1; FRS1A; FRS2A; SNT-1; FRS2alpha
Reactivity
Human
Applications
Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
Purity
Protein A purification
Synonyms
FRS2; Monoclonal Antibody; FRS2 Monoclonal Antibody; FGFR signaling adaptor SNT; FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast growth factor receptor substrate 2; FRS 2; FRS2A; FRS2alpha; SNT 1; SNT; SNT-1; SNT1; Suc 1 Associated Neurotrophic Factor Target; Suc1 associated neurotrophic factor target 1; Suc1-associated neurotrophic factor target 1; anti-FRS2 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG3
Clone Number
19
Purity/Purification
Protein A purification
Concentration
1mg/mL (varies by lot)
Sequence Length
508
Applicable Applications for anti-FRS2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes
WB: 1:500-1:5000
IHC: 1:50-1:500
IF: 1:20-1:200
IHC: 1:50-1:500
IF: 1:20-1:200
Immunogen
Fusion protein of FRS2
Buffer
PBS with 0.02% sodium azide, 50% glycerol, PH7.3
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Western Blot (WB)
(Western Blot analysis of MCF-7 cells using FRS2 Monoclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of MCF-7 cells using FRS2 Monoclonal Antibody at dilution of 1:1000)
Related Product Information for anti-FRS2 antibody
Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) has an alternative name as SNT-1, it is an adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. FRS2 is a 508 amino-acid protein, which is phosphorylated on tyrosine residues. The molecular weight of non-phosphorylated FRS2 is 57-68 kDa, but phosphorylated FRS2 is 80-90 kDa. Phosphorylation of FRS2 is associated with activation of a number of MAP kinases. Allele-specific regulation of FGFR2 mRNA expression with a mildly increased breast cancer risk has been reported.
Product Categories/Family for anti-FRS2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Calculated: 60kDa
Observed: 68kDa
Observed: 68kDa
NCBI Official Full Name
fibroblast growth factor receptor substrate 2
NCBI Official Synonym Full Names
fibroblast growth factor receptor substrate 2
NCBI Official Symbol
FRS2
NCBI Official Synonym Symbols
SNT; SNT1; FRS1A; FRS2A; SNT-1; FRS2alpha
NCBI Protein Information
fibroblast growth factor receptor substrate 2
UniProt Protein Name
Fibroblast growth factor receptor substrate 2
Protein Family
UniProt Gene Name
FRS2
UniProt Synonym Gene Names
FGFR substrate 2; SNT-1
Uniprot Description
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Research Articles on FRS2
Similar Products
Product Notes
The FRS2 frs2 (Catalog #AAA2541920) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The FRS2 Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FRS2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA). WB: 1:500-1:5000 IHC: 1:50-1:500 IF: 1:20-1:200. Researchers should empirically determine the suitability of the FRS2 frs2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FRS2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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