Mouse FOXL1 Monoclonal Antibody | anti-FOXL1 antibody

FOXL1 (Forkhead Box L1, FKH6, FKHL11, FREAC7) (PE)

Cat. Num. AAA6184730

• Gene Names: FOXL1; FKH6; FKHL11; FREAC7
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Purified
• Synonyms: FOXL1; Monoclonal Antibody; FOXL1 (Forkhead Box L1; FKH6; FKHL11; FREAC7) (PE); Forkhead Box L1; FREAC7; anti-FOXL1 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b,k
• Clone Number: 1C3
• Specificity: Recognizes FOXL1.
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-FOXL1 antibody: ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: FOXL1 (NP_005241, 132aa-240aa) full length recombinant protein with GST tag. MW of the GST tag alone is 26kD.
• Conjugate: PE
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Testing Data

(Immunoperoxidase of monoclonal antibody to FOXL1 on formalin-fixed paraffin-embedded human lung. [antibody concentration 3 ug/ml])

Immunohistochemistry (IHC)

(Immunoperoxidase of monoclonal antibody to FOXL1 on formalin-fixed paraffin-embedded human lung. [antibody concentration 3 ug/ml])

Related Product Information for anti-FOXL1 antibody

Mouse monoclonal antibody raised against a full length recombinant FOXL1.

Product Categories/Family for anti-FOXL1 antibody

Antibodies; Transcription Factors

References

1. Foxl1 inhibits tumor invasion and predicts outcome in human renal cancer. Yang FQ, Yang FP, Li W, Liu M, Wang GC, Che JP, Huang JH, Zheng JHInt J Clin Exp Pathol. 2013 Dec 15;7(1):110-22. eCollection 2013.

NCBI and Uniprot Product Information

• NCBI GI #: 22779860
• NCBI GeneID: 2300
• NCBI Accession #: NP_005241
• NCBI GenBank Nucleotide #: NM_005250
• UniProt Accession #: Q12952
• Molecular Weight: 36kDa
• NCBI Official Full Name: forkhead box protein L1
• NCBI Official Synonym Full Names: forkhead box L1
• NCBI Official Symbol: FOXL1
• NCBI Official Synonym Symbols: FKH6; FKHL11; FREAC7
• NCBI Protein Information: forkhead box protein L1
• UniProt Protein Name: Forkhead box protein L1
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXL1
• UniProt Synonym Gene Names: FKHL11; FREAC7; FREAC-7
• UniProt Entry Name: FOXL1_HUMAN

NCBI Description

This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. [provided by RefSeq, Nov 2012]

Uniprot Description

FOXL1: Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 16q24

Cellular Component: nucleus

Molecular Function: DNA binding; sequence-specific DNA binding; DNA bending activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; multicellular organismal development; heart development; proteoglycan biosynthetic process; regulation of Wnt receptor signaling pathway; visceral mesoderm-endoderm interaction involved in midgut development