Follicle Stimulating Hormone (FSH) Monoclonal Antibody | anti-FSHB antibody

MAb to FSH

Cat. Num. AAA311616

• Applications: ELISA
• Purity: >90% pure (SDS-PAGE). Protein A chromatography. Product is 0.2um filtered.
• Synonyms: Follicle Stimulating Hormone (FSH); Monoclonal Antibody; MAb to FSH; Monoclonal Antibody to Follicle Stimulating Hormone (FSH); anti-FSHB antibody

• Host: Host: Mouse; Source: Ascites
• Clonality: Monoclonal
• Isotype: IgG2a, kappa
• Clone Number: 090-10264
• Specificity: Follicle Stimulating Hormone (FSH); Follicle Stimulating Hormone (FSH). Reacts with intact molecule. Does not cross react with other common alpha hormones.
• Purity/Purification: >90% pure (SDS-PAGE). Protein A chromatography. Product is 0.2um filtered.
• Form/Format: Purified, Liquid
• Concentration: 5.61mg/ml (OD280nm, E^0.1% = 1.4) (varies by lot)

• Applicable Applications for anti-FSHB antibody: EIA/ELISA, Immunoassay Antibody Pairs
• Immunogen: High purity intact FSH from human pituitary gland.
• Affinity Constant: 3.9 x 10^9
• Buffer: 10mM Phosphate, pH 7.4 containing 150mM Sodium chloride
• Preservative: 0.1% Sodium azide
• Important Note: Centrifuge before opening to ensure complete recovery of vial contents.
• Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
• Preparation and Storage: Short term (up to 7 days) store at 2 to 8 degree C. Long term, aliquot and store at <-40 degree C. If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used. Avoid repeated freeze/th

Product Categories/Family for anti-FSHB antibody

Monoclonal Antibodies to Hormones and Steroids

NCBI and Uniprot Product Information

• NCBI GI #: 182762
• NCBI GeneID: 2488
• UniProt Accession #: P01225; Q14D61; A2TF08; A5JVV3; Q1W658; Q27RP3
• Molecular Weight: 14,700 Da
• NCBI Official Full Name: follicle-stimulating hormone
• NCBI Official Synonym Full Names: follicle stimulating hormone, beta polypeptide
• NCBI Official Symbol: FSHB
• NCBI Protein Information: follitropin subunit beta; FSH-B; FSH-beta; OTTHUMP00000232881; OTTHUMP00000232882; follitropin beta chain; follitropin, beta chain; follicle-stimulating hormone beta subunit
• UniProt Protein Name: Follitropin subunit beta
• Protein Family: Follitropin
• UniProt Gene Name: FSHB
• UniProt Entry Name: FSHB_HUMAN

NCBI Description

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq]

Uniprot Description

Function: Stimulates development of follicle and spermatogenesis in the reproductive organs.

Subunit structure: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Subcellular location: Secreted.

Involvement in disease: Defects in FSHB are a cause of isolated follicle-stimulating hormone deficiency (IFSHD) [

MIM:229070]. Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. Ref.15 Ref.16 Ref.17

Pharmaceutical use: Available under the names Gonal-F or Metrodin HP (Serono) and Puregon (Organon). Used in the treatment of infertility in women with proven hypopituitarism or who have not responded to clomifene; or in superovulation treatment for assisted conception (such as in vitro fertilization). Metrodin HP is also used in the treatment of hypogonadotrophic hypogonadism in men for the stimulation of spermatogenesis.

Sequence similarities: Belongs to the glycoprotein hormones subunit beta family.