Mouse anti-Human Ficolin-2 Monoclonal Antibody | anti-Fcnb antibody
Ficolin-2, Human, mAb GN4
Gene Names
Fcnb; Fcn2
Reactivity
Human
Applications
Immunoprecipitation
Synonyms
Ficolin-2; Monoclonal Antibody; Human; mAb GN4; anti-Fcnb antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG1
Form/Format
1 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine Serum albumin.
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)
Sequence Length
314
Applicable Applications for anti-Fcnb antibody
Immunoassay (IA), Immunoprecipitation (IP)
Preparation and Storage
Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year.
Related Product Information for anti-Fcnb antibody
Product Description: The monoclonal antibody GN4 recognizes human Ficolin-2, also known as L-ficolin. Ficolins are a family of pattern recognition molecules containing both a collagen-like domain and a fibrinogen-like domain that are capable of activating the complement system, through association with MASPs, on the surface of microorganisms. In human, three Ficolins are known: Ficolin-1 (M-ficolin), Ficolin-2 (L-ficolin), and Ficolin-3 (H-ficolin). Ficolin-1, is mainly expressed by monocytes, granulocytes and lung cells and is present locally in areas of inflammation. Ficolin-2 (also L-ficolin, ficolin L, EBP-37 or hucolin) is produced primarily by the liver. The association between Ficolin-2 and MASPs/sMAP is Ca2+-dependent. MASPs in Ficolin-2-MASP complexes have proteolytic activities for C4, C2 and C3. Ficolin-2 also shows opsonic activity.
References
1. Matsushita, M et al; Activation of the lectin complement pathway by ficolins. Int Immunopharmacol 2001, 1: 359 2. Matsushita, M et al; Activation of the lectin complement pathway by H-ficolin (Hakata antigen). J of Immunol 2002, 168: 3502
3. Matsushita, M et al; The role of ficolins in innate immunity. Immunobiol 2002, 205: 490
3. Matsushita, M et al; The role of ficolins in innate immunity. Immunobiol 2002, 205: 490
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
33,984 Da
NCBI Official Full Name
ficolin-2
NCBI Official Synonym Full Names
ficolin B
NCBI Official Symbol
Fcnb
NCBI Official Synonym Symbols
Fcn2
NCBI Protein Information
ficolin-2; L-ficolin; ficolin-B; ficolin-beta; collagen/fibrinogen domain-containing protein 2
UniProt Protein Name
Ficolin-2
Protein Family
UniProt Gene Name
Fcn2
UniProt Synonym Gene Names
Fcnb
UniProt Entry Name
FCN2_MOUSE
Uniprot Description
FCN2: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. Belongs to the ficolin lectin family. 2 isoforms of the human protein are produced by alternative splicing.
Cellular Component: collagen; extrinsic to external side of plasma membrane; extracellular region
Molecular Function: G-protein-coupled receptor binding; carbohydrate binding; sialic acid binding; pattern recognition receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of virion penetration into host cell; immune system process; cell surface pattern recognition receptor signaling pathway; innate immune response; complement activation, lectin pathway; recognition of apoptotic cell
Research Articles on Fcnb
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Product Notes
The Fcnb fcn2 (Catalog #AAA584022) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Ficolin-2, Human, mAb GN4 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Ficolin-2 can be used in a range of immunoassay formats including, but not limited to, Immunoassay (IA), Immunoprecipitation (IP). . Researchers should empirically determine the suitability of the Fcnb fcn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ficolin-2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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