Mouse anti-Human FCER2 Monoclonal Antibody | anti-FCER2 antibody

FCER2 Antibody

Cat. Num. AAA9602778

• Gene Names: FCER2; CD23; FCE2; CD23A; IGEBF; CLEC4J; BLAST-2
• Reactivity: Human
• Applications: ELISA, Flow Cytometry, Functional Assay
• Purity: Affinity-Chromatography
• Synonyms: FCER2; Monoclonal Antibody; FCER2 Antibody; Blast 2; BLAST-2; Blast2; C type lectin domain family 4 member J; C-type lectin domain family 4 member J; C-type lectin domain family 4; member J; CD 23; CD 23A; CD23; CD23 antigen; CD23A; CLEC 4J; CLEC4J; Fc epsilon receptor II; Fc epsilon RII; Fc fragment of IgE low affinity II receptor for; Fc fragment of IgE receptor II; Fc fragment of IgE; low affinity II; receptor for (CD23); Fc of IgE; Fc receptor IgE low affinity II alpha polypeptide; Fc receptor; IgE; alpha polypeptide; isoform CRA_a; Fc-epsilon-RII; FCE 2; FCE2; FCER 2; Fcer2; FCER2_HUMAN; FCER2A; FceRII; IgE binding factor; IgE receptor lymphocyte; IgE-binding factor; IGEBF; Immunoglobulin E binding factor; Immunoglobulin E receptor; Immunoglobulin E-binding factor; Immunoglobulin epsilon chain; LEUKOCYTE ANTIGEN CD23; Low Affinity IgE Receptor; Low affinity immunoglobulin epsilon Fc receptor; Low affinity immunoglobulin epsilon Fc receptor membrane bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form; Ly-42; Ly42; Lymphocyte antigen CD23; Lymphocyte IgE receptor; MGC93219; anti-FCER2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Specificity: FCER2 antibody detects endogenous levels of total FCER2
• Purity/Purification: Affinity-Chromatography
• Form/Format: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 320

• Applicable Applications for anti-FCER2 antibody: ELISA (EIA), Flow Cytometry (FC/FACS)
• Application Notes: ELISA: 1:10000; FC/FACS: 1:200-1:400
• Immunogen: Purified recombinant fragment of human FCER2 expressed in E. Coli
• Subcellular Location: Cell Membrane. Secreted. Also exists as a soluble excreted form.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Testing Data

()

Related Product Information for anti-FCER2 antibody

Description: The human leukocyte differentiation antigen CD23 (FCE2) is a key molecule for B-cell activation and growth. It is the low-affinity receptor for IgE. The truncated molecule can be secreted, then functioning as a potent mitogenic growth factor.(supplied by OMIM). It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a membrane bound cytokine, in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.
Function: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
Subunit Structure: Homotrimer.
Post-translational Modifications: N-and O-glycosylated. The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.

NCBI and Uniprot Product Information

• NCBI GI #: 334085205
• NCBI GeneID: 2208
• NCBI Accession #: NP_001193948.2
• NCBI GenBank Nucleotide #: NM_001207019.2
• UniProt Accession #: P06734
• Molecular Weight: Observed: 37 kDa; Predicted: 37 kDa
• NCBI Official Full Name: low affinity immunoglobulin epsilon Fc receptor isoform b
• NCBI Official Synonym Full Names: Fc fragment of IgE receptor II
• NCBI Official Symbol: FCER2
• NCBI Official Synonym Symbols: CD23; FCE2; CD23A; IGEBF; CLEC4J; BLAST-2
• NCBI Protein Information: low affinity immunoglobulin epsilon Fc receptor
• UniProt Protein Name: Low affinity immunoglobulin epsilon Fc receptor
• Protein Family: Low affinity immunoglobulin epsilon Fc receptor
• UniProt Gene Name: FCER2
• UniProt Synonym Gene Names: CD23A; CLEC4J; FCE2; IGEBF

NCBI Description

The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Uniprot Description

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).