Mouse FBXO18 Monoclonal Antibody | anti-FBXO18 antibody

FBXO18 (F-box Only Protein 18, F-box DNA Helicase 1, FBH1, Fbx18, FLJ14590, MGC131916, MGC141935, MGC141937)

Cat. Num. AAA600289

• Gene Names: FBXO18; FBH1; Fbx18; FLJ14590; MGC131916; MGC141935; MGC141937
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: FBXO18; Monoclonal Antibody; FBXO18 (F-box Only Protein 18; F-box DNA Helicase 1; FBH1; Fbx18; FLJ14590; MGC131916; MGC141935; MGC141937); Anti -FBXO18 (F-box Only Protein 18; anti-FBXO18 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 8C144
• Specificity: Recognizes human FBXO18.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

• Applicable Applications for anti-FBXO18 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blotting.; Dilution: Western Blotting: 1:1000-1:2000
• Immunogen: Partial sequence of recombinant full-length protein to human FBXO18
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

Product Categories/Family for anti-FBXO18 antibody

Antibodies; Abs to Ubiquitin Ligases

NCBI and Uniprot Product Information

• NCBI GI #: 30795119
• NCBI GeneID: 84893
• NCBI Accession #: NP_835363.1
• NCBI GenBank Nucleotide #: NM_178150.1
• UniProt Accession #: Q14DG0; Q2TAK1; Q5JVB6; Q66K33; Q8NFZ0
• Molecular Weight: 117,614 Da
• NCBI Official Full Name: F-box only protein 18 isoform 2
• NCBI Official Synonym Full Names: F-box protein, helicase, 18
• NCBI Official Symbol: FBXO18
• NCBI Official Synonym Symbols: FBH1; Fbx18; FLJ14590; MGC131916; MGC141935; MGC141937
• NCBI Protein Information: F-box only protein 18; OTTHUMP00000019016; OTTHUMP00000019017; F-box DNA helicase 1; F-box only protein, helicase, 18
• UniProt Protein Name: F-box protein, helicase, 18
• Protein Family: F-box DNA helicase
• UniProt Gene Name: FBXO18
• UniProt Entry Name: Q14DG0_HUMAN

NCBI Description

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]

Uniprot Description

FBXO18: DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction. Belongs to the helicase family. UvrD subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.12; Helicase

Chromosomal Location of Human Ortholog: 10p15.1

Cellular Component: nucleus

Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; ATP binding

Biological Process: positive regulation of protein amino acid phosphorylation; DNA catabolic process, endonucleolytic; DNA duplex unwinding