anti-Human ERCC1 Monoclonal Antibody | anti-ERCC1 antibody
Anti - ERCC1 (Excision Repair Cross Complement)
Reactivity
Human
Purity
Purified by Protein A/G column chromatography
Synonyms
ERCC1; Monoclonal Antibody; Anti - ERCC1 (Excision Repair Cross Complement); ERCC1 (Excision Repair Cross Complement); anti-ERCC1 antibody
Host
Host: Mouse
Source: Human
Source: Human
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
3H18
Specificity
Recognizes human ERCC1.
Purity/Purification
Purified by Protein A/G column chromatography
Form/Format
Affinity Purified
Supplied as a liquid in 10 mM PBS, pH 7.4, 0.2% BSA, 0.1% sodium azide, 40% glycerol.
Supplied as a liquid in 10 mM PBS, pH 7.4, 0.2% BSA, 0.1% sodium azide, 40% glycerol.
Concentration
0.2mg/ml (varies by lot)
Immunogen
Purified Recombinant His-tagged Human ERCC1 protein
Preparation and Storage
-20 degree C
Related Product Information for anti-ERCC1 antibody
Exchange Repair Cross Complementing (ERCC1) gene encodes 33-36kD protein involved in DNA repair. It is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. The structure-specific ERCC1/XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV-induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross-links. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3\' of the DNA lesion while the ERCC1-XPF complex makes the 5\' incision. Elevated levels of ERCC1 have also been reported in Cisplatin-resistant cells.
Product Categories/Family for anti-ERCC1 antibody
References
• 1. Miura M et al (1996) Exp. Cell res. 226:126-132.
• 2. Hayashi T et al (1998) Mut. Res. 407:269-276.
• 3. Delaat Wl et al (1998) J. Biol. Chem. 273:7835-7842.
• 4. lee-Kwon W et al (1998) Biochem. J. 331:591-597.
• 5. Li Q et al (1999) Biochem. Pharmacol. 57:347-353.
• 2. Hayashi T et al (1998) Mut. Res. 407:269-276.
• 3. Delaat Wl et al (1998) J. Biol. Chem. 273:7835-7842.
• 4. lee-Kwon W et al (1998) Biochem. J. 331:591-597.
• 5. Li Q et al (1999) Biochem. Pharmacol. 57:347-353.
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Product Notes
The ERCC1 (Catalog #AAA604283) is an Antibody produced from Host: Mouse Source: Human and is intended for research purposes only. The product is available for immediate purchase. The Anti - ERCC1 (Excision Repair Cross Complement) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "ERCC1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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