Mouse EOSINOPHIL MAJOR BASIC PROTEIN Monoclonal Antibody | anti-PRG2 antibody
MOUSE ANTI HUMAN EOSINOPHIL MAJOR BASIC PROTEIN
Purified IgG - liquid
Immunohistology - Paraffin: Minimum Dilution: 1/20; Maximum Dilution: 1/50; Application Note: This product requires enzymatic pre-treatment of paraffin sections prior to staining. Pepsin is recommended for this purpose. NB. Heat-mediated antigen retrieval methods should not be used.
0.1% Bovine Serum Albumin
It is recommended to aliquot and store at -20°C on receipt.
When thawed, aliquot the sample as needed.
Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody.
Storage in frost-free freezers is not recommended
Species Cross Reactivity Note: N.B. Antibody reactivity and working conditions may vary between species. Cross reactivity is derived from testing within our laboratories
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Uniprot Description
PRG2: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Protein type: Secreted, signal peptide; Vesicle; Secreted
Chromosomal Location of Human Ortholog: 11q12
Cellular Component: transport vesicle; extracellular region
Molecular Function: heparin binding; carbohydrate binding
Biological Process: positive regulation of interleukin-4 production; negative regulation of interleukin-10 production; defense response to bacterium; immune response; defense response to nematode
Research Articles on PRG2
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Product Notes
The PRG2 prg2 (Catalog #AAA219842) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MOUSE ANTI HUMAN EOSINOPHIL MAJOR BASIC PROTEIN reacts with Guinea Pig (Weak), Rat and may cross-react with other species as described in the data sheet. AAA Biotech's EOSINOPHIL MAJOR BASIC PROTEIN can be used in a range of immunoassay formats including, but not limited to, Immunohistology Frozen*, ELISA (EIA), Immunohistology Paraffin*. Immunohistology - Frozen: Minimum Dilution: 1/20; Maximum Dilution: 1/50; Application Note: It is recommended that sections are fixed in a 1:1 mixture of acetone and methanol and air-dried for 1 hour. Good results may be achieved via staining. Immunohistology - Paraffin: Minimum Dilution: 1/20; Maximum Dilution: 1/50; Application Note: This product requires enzymatic pre-treatment of paraffin sections prior to staining. Pepsin is recommended for this purpose. NB. Heat-mediated antigen retrieval methods should not be used. Researchers should empirically determine the suitability of the PRG2 prg2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EOSINOPHIL MAJOR BASIC PROTEIN, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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