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Mouse anti-Human E6AP Monoclonal Antibody | anti-E6AP antibody

E6AP (human) monoclonal antibody (EX-8)

Gene Names
UBE3A; AS; ANCR; E6-AP; HPVE6A; EPVE6AP
Reactivity
Human
Applications
Western Blot
Synonyms
E6AP; Monoclonal Antibody; E6AP (human) monoclonal antibody (EX-8); UBE3A; E6AP (human); mAb (EX-8); anti-E6AP antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
EX-8
Specificity
Recognizes human E6AP.
Form/Format
Liquid. In PBS containing 0.09% sodium azide.
Sequence Length
875
Applicable Applications for anti-E6AP antibody
Western Blot (WB)
Application Notes
Western Blot (1:1'000).
Immunogen
Recombinant human E6AP.
Preparation and Storage
Long Term: -20 degree C
Avoid freeze/thaw cycles.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
100,102 Da
NCBI Official Full Name
Ubiquitin-protein ligase E3A
NCBI Official Synonym Full Names
ubiquitin protein ligase E3A
NCBI Official Symbol
UBE3A
NCBI Official Synonym Symbols
AS; ANCR; E6-AP; HPVE6A; EPVE6AP
NCBI Protein Information
ubiquitin-protein ligase E3A
UniProt Protein Name
Ubiquitin-protein ligase E3A
UniProt Gene Name
UBE3A
UniProt Synonym Gene Names
E6AP; EPVE6AP; HPVE6A

NCBI Description

This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990).

Research Articles on E6AP

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Product Notes

The E6AP ube3a (Catalog #AAA565789) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The E6AP (human) monoclonal antibody (EX-8) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's E6AP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot (1:1'000). Researchers should empirically determine the suitability of the E6AP ube3a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "E6AP, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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