Flow Cytometry (FC/FACS)
(Fig-1: Intracellular FLOW staining of PMA treated Jurkat cells using 0.5 ug of antibody. Green represents FITC conjugated IgG1 isotype control, Red represents FITC conjugated DNMT3a (10-7004-F).)
Mouse anti-Human DNMT3a Monoclonal Antibody | anti-DNMT3a antibody
Monoclonal Antibody to DNMT3a (Clone: ABM1F35) FITC Conjugated
Protein G Chromatography
Protein G Chromatography
Flow Cytometry (FC/FACS)
(Fig-1: Intracellular FLOW staining of PMA treated Jurkat cells using 0.5 ug of antibody. Green represents FITC conjugated IgG1 isotype control, Red represents FITC conjugated DNMT3a (10-7004-F).)
Flow Cytometry (FC/FACS)
(Fig-1: Intracellular FLOW staining of PMA treated Jurkat cells using 0.5 ug of antibody. Green represents FITC conjugated IgG1 isotype control, Red represents FITC conjugated DNMT3a (10-7004-F).)
NCBI and Uniprot Product Information
NCBI Description
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]
Uniprot Description
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Research Articles on DNMT3a
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Product Notes
The DNMT3a dnmt3a (Catalog #AAA669018) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Monoclonal Antibody to DNMT3a (Clone: ABM1F35) FITC Conjugated reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DNMT3a can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). FC/FACS: 0.5-2 ug/10^6 cells. Researchers should empirically determine the suitability of the DNMT3a dnmt3a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DNMT3a, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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