Western Blot (WB)
(Western blot detection of DFNA5/GSDME in U251MG,U2OS,HepG2,Hela cell lysates using DFNA5/GSDME Rabbit mAb(1:500 diluted). Predicted band size:55kDa. Observed band size:55kDa.)
Rabbit DFNA5/GSDME Monoclonal Antibody | anti-GSDME antibody
DFNA5/GSDME Rabbit mAb
FC/FACS: 1:20
IP: 1:20
Western Blot (WB)
(Western blot detection of DFNA5/GSDME in U251MG,U2OS,HepG2,Hela cell lysates using DFNA5/GSDME Rabbit mAb(1:500 diluted). Predicted band size:55kDa. Observed band size:55kDa.)
Western Blot (WB)
(Western blot detection of DFNA5/GSDME in U251MG,U2OS,HepG2,Hela cell lysates using DFNA5/GSDME Rabbit mAb(1:500 diluted). Predicted band size:55kDa. Observed band size:55kDa.)
Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 (PubMed:16897187, PubMed:18223688).
NCBI and Uniprot Product Information
Uniprot Description
DFNA5: Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. Defects in DFNA5 are the cause of deafness autosomal dominant type 5 (DFNA5). DFNA5 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Is a tumor suppressor gene with an important role in major types of tumors. Could be a valuable molecular marker in cancer. Belongs to the gasdermin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 7p15
Cellular Component: cytoplasm
Biological Process: negative regulation of cell proliferation; sensory perception of sound; inner ear receptor cell differentiation; apoptosis
Disease: Deafness, Autosomal Dominant 5
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Product Notes
The GSDME dfna5 (Catalog #AAA4752702) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DFNA5/GSDME Rabbit mAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DFNA5/GSDME can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Flow Cytometry (FC/FACS), Immunoprecipitation (IP). WB: 1:1000 FC/FACS: 1:20 IP: 1:20. Researchers should empirically determine the suitability of the GSDME dfna5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DFNA5/GSDME, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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