Mouse anti-Human DAXX Monoclonal Antibody | anti-DAXX antibody

Anti-DAXX Purified

Cat. Num. AAA1800535

• Gene Names: DAXX; DAP6; EAP1; BING2; SMIM40
• Reactivity: Human
• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Purity: Purified by Protein-A Affinity Chromatography
• Synonyms: DAXX; Monoclonal Antibody; Anti-DAXX Purified; death domain associated protein; DAP6; EAP1; BING2; anti-DAXX antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: DAXX-03
• Specificity: The mouse monoclonal antibody DAXX-03 reacts with C-terminal part of Daxx, a 110 kDa intracellular protein.
• Purity/Purification: Purified by Protein-A Affinity Chromatography
• Form/Format: Phosphate buffered saline (PBS) solution with 15 mM sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 740

• Applicable Applications for anti-DAXX antibody: Immunoprecipitation, Western Blot (WB), Immunocytochemistry (ICC)
• Immunogen: His6-tagged protein corresponding to amino acids 580-740 of human Daxx.
• Preparation and Storage: Store at 2-8 degree C.

Western Blot (WB)

(Western blotting analysis of Daxx expression in human U937 cell line with anti-Daxx (DAXX-03) purified.)

Related Product Information for anti-DAXX antibody

Daxx is an apoptosis-modulating death domain-associated protein with functions in transcriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1).

NCBI and Uniprot Product Information

• NCBI GI #: 48146287
• NCBI GeneID: 1616
• NCBI Official Full Name: DAXX
• NCBI Official Synonym Full Names: death domain associated protein
• NCBI Official Symbol: DAXX
• NCBI Official Synonym Symbols: DAP6; EAP1; BING2; SMIM40
• NCBI Protein Information: death domain-associated protein 6
• Protein Family: Death domain-associated protein

NCBI Description

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]