Western Blot (WB)
(Western Blot analysis of DAB2 expression in transfected 293T cell line by DAB2 monoclonal antibody (M09), clone 3D6.Lane 1: DAB2 transfected lysate (Predicted MW: 82.507 KDa).Lane 2: Non-transfected lysate.)
Mouse DAB2 Monoclonal Antibody | anti-DAB2 antibody
DAB2 (disabled Homolog 2, Mitogen-Responsive Phosphoprotein (Drosophila), DOC-2, DOC2, FLJ26626) (AP)
Gene Names
DAB2; DOC2; DOC-2
Applications
ELISA, Western Blot
Purity
Purified
Synonyms
DAB2; Monoclonal Antibody; DAB2 (disabled Homolog 2; Mitogen-Responsive Phosphoprotein (Drosophila); DOC-2; DOC2; FLJ26626) (AP); disabled Homolog 2; FLJ26626; anti-DAB2 antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
3D6
Specificity
Recognizes DAB2.
Purity/Purification
Purified
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Sequence Length
770
Applicable Applications for anti-DAB2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
Applications are based on unconjugated antibody.
Immunogen
DAB2 (AAH03064, 1aa-770aa) full-length recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Conjugate
AP
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Western Blot (WB)
(Western Blot analysis of DAB2 expression in transfected 293T cell line by DAB2 monoclonal antibody (M09), clone 3D6.Lane 1: DAB2 transfected lysate (Predicted MW: 82.507 KDa).Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of DAB2 expression in transfected 293T cell line by DAB2 monoclonal antibody (M09), clone 3D6.Lane 1: DAB2 transfected lysate (Predicted MW: 82.507 KDa).Lane 2: Non-transfected lysate.)
Related Product Information for anti-DAB2 antibody
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta). [provided by RefSeq]
Product Categories/Family for anti-DAB2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
Disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
NCBI Official Synonym Full Names
DAB adaptor protein 2
NCBI Official Symbol
DAB2
NCBI Official Synonym Symbols
DOC2; DOC-2
NCBI Protein Information
disabled homolog 2
Protein Family
NCBI Description
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Research Articles on DAB2
Similar Products
Product Notes
The DAB2 (Catalog #AAA6164689) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's DAB2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the DAB2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DAB2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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