Mouse Cytokeratin 2 Monoclonal Antibody | anti-KRT75 antibody
Cytokeratin 2 antibody
Reactivity
Amphibia, Bovine, Human
Applications
Immunofluorescence, Immunohistochemistry, Western Blot
Purity
Protein A affinity chromatography
Synonyms
Cytokeratin 2; Monoclonal Antibody; Cytokeratin 2 antibody; Monoclonal Cytokeratin 2; Anti-Cytokeratin 2; Cytokeratin Type II; Cytokeratin -2; anti-KRT75 antibody
Host
Mouse
Reactivity
Amphibia, Bovine, Human
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
Kspan1-8
Specificity
Human cytokeratin 2
Purity/Purification
Protein A affinity chromatography
Form/Format
Supplied as a lyophilized powder. Reconstitute in 1 ml dist. water (final solution contains 0.09 % NaN3, 0.5% BSA in PBS buffer, pH 7.4)
Sequence Length
551
Applicable Applications for anti-KRT75 antibody
Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin, Western Blot (WB)
Application Notes
IHC-F: 1:10
Biological Significance
Type II keratins (or Type II cytokeratins) constitutes the Type II intermediate filaments (IFs) of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells. The type 2 cytokeratins consist of basic or neutral, high molecular weight proteins which in vivo are arranged in pairs of heterotypic Type I and Type II keratin chains, coexpressed during differentiation of simple and stratified epithelial tissues.
Cross-Reactivity
Amphibia, bovine, human
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
Cytokeratin 2 antibody was raised in mouse using cytoskeletal proteins from cultured human MCF-7 cells as the immunogen.
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-KRT75 antibody
Mouse monoclonal Cytokeratin 2 antibody
Product Categories/Family for anti-KRT75 antibody
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
59,560 Da
NCBI Official Full Name
cytokeratin type II
UniProt Protein Name
Keratin, type II cytoskeletal 75
Protein Family
UniProt Gene Name
KRT75
UniProt Synonym Gene Names
K6HF; KB18; CK-75; hK6hf; K75
UniProt Entry Name
K2C75_HUMAN
Uniprot Description
KRT75: Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle. Defects in KRT75 may be a cause of loose anagen hair syndrome (LAHS). In LAHS, anagen hairs are easily pulled from the scalp. The hair is relatively sparse and does not grow long. Hair of fair color and hair shafts of reduced caliber, and an early age of onset are features. Usually the hairs are not fragile and there are no areas of breakage. Belongs to the intermediate filament family.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: keratin filament
Molecular Function: structural molecule activity
Biological Process: hemopoietic progenitor cell differentiation
Disease: Pseudofolliculitis Barbae
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Product Notes
The Cytokeratin 2 krt75 (Catalog #AAA531056) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Cytokeratin 2 antibody reacts with Amphibia, Bovine, Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cytokeratin 2 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin, Western Blot (WB). IHC-F: 1:10. Researchers should empirically determine the suitability of the Cytokeratin 2 krt75 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cytokeratin 2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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