Mouse anti-Human Cytochrome P450 17A1 Monoclonal Antibody | anti-CYP17A1 antibody

Cytochrome P450 17A1 Antibody

Cat. Num. AAA9215368

• Gene Names: CYP17A1; CPT7; CYP17; S17AH; P450C17
• Reactivity: Human
• Applications: Western Blot
• Synonyms: Cytochrome P450 17A1; Monoclonal Antibody; Cytochrome P450 17A1 Antibody; Purified Mouse Monoclonal Antibody (Mab); 20 lyase; CP17A_HUMAN; CPT7; CYP17; CYP17A1; CYPXVII; Cytochrome P450 family 17; Cytochrome P450 family 17 subfamily A polypeptide 1; Cytochrome p450 subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia; Cytochrome p450 XVIIA1; Cytochrome P450-C17; Cytochrome P450c17; OTTHUMP00000020382; P450 C17; P450c17; S17AH; Steroid 17 alpha hydroxylase/17; Steroid 17 alpha monooxygenase; Steroid 17-alpha-hydroxylase/17; Steroid 17-alpha-monooxygenase.; anti-CYP17A1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Form/Format: Ascites
• Sequence Length: 508

• Applicable Applications for anti-CYP17A1 antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:1000
• Antigen Source: Human
• Antigen Type: Recombinant Protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Western blot detection of Cytochrome P450 17A1 in Hela,HepG2 and A549 cell lysates using Cytochrome P450 17A1 mouse mAb (1:1000 diluted).Predicted band size:60KDa.Observed band size:60KDa.)

Related Product Information for anti-CYP17A1 antibody

Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Product Categories/Family for anti-CYP17A1 antibody

Cancer; Cardiovascular; Metabolism; Signal transduction

References

Chung B.-C.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:407-411(1987). Picado-Leonard J.,et al.DNA 6:439-448(1987). Bradshaw K.D.,et al.Mol. Endocrinol. 1:348-354(1987). Brentano S.T.,et al.Mol. Endocrinol. 4:1972-1979(1990). Kagimoto M.,et al.Mol. Endocrinol. 2:564-570(1988).

NCBI and Uniprot Product Information

• NCBI GI #: 4503195
• NCBI GeneID: 1586
• NCBI Accession #: NP_000093.1
• NCBI GenBank Nucleotide #: NM_000102.3
• UniProt Accession #: P05093; Q5TZV7
• Molecular Weight: 57371
• NCBI Official Full Name: steroid 17-alpha-hydroxylase/17,20 lyase
• NCBI Official Synonym Full Names: cytochrome P450, family 17, subfamily A, polypeptide 1
• NCBI Official Symbol: CYP17A1
• NCBI Official Synonym Symbols: CPT7; CYP17; S17AH; P450C17
• NCBI Protein Information: steroid 17-alpha-hydroxylase/17,20 lyase
• UniProt Protein Name: Steroid 17-alpha-hydroxylase/17,20 lyase
• Protein Family: Steroid 17-alpha-hydroxylase/17,20 lyase
• UniProt Gene Name: CYP17A1
• UniProt Synonym Gene Names: CYP17; S17AH; Cytochrome P450c17
• UniProt Entry Name: CP17A_HUMAN

NCBI Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]

Uniprot Description

CYP17A1: Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5). AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: salt wasting (SW, the most severe type), simple virilizing (SV, less severely affected patients), with normal aldosterone biosynthesis, non-classic form or late onset (NC or LOAH), and cryptic (asymptomatic). Belongs to the cytochrome P450 family.

Protein type: EC 1.14.99.9; EC 4.1.2.30; Lipid Metabolism - C21-steroid hormone; Oxidoreductase

Chromosomal Location of Human Ortholog: 10q24.3

Cellular Component: endoplasmic reticulum membrane; mitochondrion; cell soma; axon; endoplasmic reticulum

Molecular Function: 17-alpha-hydroxyprogesterone aldolase activity; steroid 17-alpha-monooxygenase activity; iron ion binding; heme binding; oxygen binding

Biological Process: steroid metabolic process; xenobiotic metabolic process; hormone biosynthetic process; progesterone metabolic process; androgen biosynthetic process; glucocorticoid biosynthetic process; sex differentiation; steroid biosynthetic process; sterol metabolic process

Disease: Adrenal Hyperplasia, Congenital, Due To 17-alpha-hydroxylase Deficiency