Immunohistochemistry (IHC)
(Fig-1: Immunohistochemical analysis of Cyclin D1 in Mantle cell using Cyclin D1 antibody (Clone: ABM47F5) at 5 ug/ml.)
Mouse anti-Human Cyclin D1 Monoclonal Antibody | anti-CCNDBP1 antibody
Monoclonal Antibody to Cyclin D1 (Clone: ABM47F5)
Protein G Chromatography
Protein G Chromatography
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Immunohistochemistry (IHC)
(Fig-1: Immunohistochemical analysis of Cyclin D1 in Mantle cell using Cyclin D1 antibody (Clone: ABM47F5) at 5 ug/ml.)
Immunohistochemistry (IHC)
(Fig-1: Immunohistochemical analysis of Cyclin D1 in Mantle cell using Cyclin D1 antibody (Clone: ABM47F5) at 5 ug/ml.)
NCBI and Uniprot Product Information
NCBI Description
This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009]
Uniprot Description
CCNDBP1: May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription. Belongs to the CCNDBP1 family. 4 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 15q15.2
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding
Research Articles on CCNDBP1
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Product Notes
The CCNDBP1 ccndbp1 (Catalog #AAA668314) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Monoclonal Antibody to Cyclin D1 (Clone: ABM47F5) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cyclin D1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 5-10 ug/ml. Researchers should empirically determine the suitability of the CCNDBP1 ccndbp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cyclin D1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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