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Western Blot (WB)
(Western Blot detection against Immunogen (31.17kD).)
Mouse anti-Human, Rat CXCR4 Monoclonal Antibody | anti-CXCR4 antibody
CXCR4 (C-X-C Chemokine Receptor Type 4, FB22, Fusin, HM89, LCR1, Leukocyte-derived Seven Transmembrane Domain Receptor, NPYRL, Stromal Cell-derived Factor 1 Receptor, CD184) (PE)
Gene Names
CXCR4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; D2S201E
Reactivity
Human, Rat
Applications
ELISA, Western Blot
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
CXCR4; Monoclonal Antibody; CXCR4 (C-X-C Chemokine Receptor Type 4; FB22; Fusin; HM89; LCR1; Leukocyte-derived Seven Transmembrane Domain Receptor; NPYRL; Stromal Cell-derived Factor 1 Receptor; CD184) (PE); anti-CXCR4 antibody
Host
Mouse
Reactivity
Human, Rat
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
2G9
Specificity
Recognizes human CXCR4. Species Crossreactivity: rat.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Applicable Applications for anti-CXCR4 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
Applications are based on unconjugated antibody.
Immunogen
Partial recombinant corresponding to aa1-47 from CXCR4 (AAH20968) with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYS
Conjugate
PE
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Western Blot (WB)
(Western Blot detection against Immunogen (31.17kD).)
Western Blot (WB)
(Western Blot detection against Immunogen (31.17kD).)
Western Blot (WB)
(CXCR4 monoclonal antibody. Western Blot analysis of CXCR4 expression in human colon.)
Western Blot (WB)
(CXCR4 monoclonal antibody. Western Blot analysis of CXCR4 expression in human colon.)
Western Blot (WB)
(CXCR4 monoclonal antibody Western Blot analysis of CXCR4 expression in human intestinal wall.)
Western Blot (WB)
(CXCR4 monoclonal antibody Western Blot analysis of CXCR4 expression in human intestinal wall.)
Testing Data
(Detection limit for recombinant GST tagged CXCR4 is 0.03ng/ml as a capture antibody.)
Testing Data
(Detection limit for recombinant GST tagged CXCR4 is 0.03ng/ml as a capture antibody.)
Related Product Information for anti-CXCR4 antibody
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.
Product Categories/Family for anti-CXCR4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
40,221 Da
NCBI Official Full Name
Homo sapiens chemokine (C-X-C motif) receptor 4, mRNA
NCBI Official Synonym Full Names
C-X-C motif chemokine receptor 4
NCBI Official Symbol
CXCR4
NCBI Official Synonym Symbols
FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; D2S201E
NCBI Protein Information
C-X-C chemokine receptor type 4
Protein Family
NCBI Description
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Research Articles on CXCR4
Similar Products
Product Notes
The CXCR4 (Catalog #AAA6157334) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CXCR4 (C-X-C Chemokine Receptor Type 4, FB22, Fusin, HM89, LCR1, Leukocyte-derived Seven Transmembrane Domain Receptor, NPYRL, Stromal Cell-derived Factor 1 Receptor, CD184) (PE) reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CXCR4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the CXCR4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CXCR4, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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