Western Blot (WB)
(Western Blot detection against Immunogen (37.84kD).)
Mouse anti-Human, Rat CTNND2 Monoclonal Antibody | anti-CTNND2 antibody
CTNND2 (Catenin delta-2, Delta-catenin, GT24, Neural Plakophilin-related ARM-repeat Protein, NPRAP, Neurojungin, NPRAP)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot detection against Immunogen (37.84kD).)
Western Blot (WB)
(Western Blot detection against Immunogen (37.84kD).)
Western Blot (WB)
(CTNND2 monoclonal antibody. Western Blot analysis of CTNND2 expression in PC-12.)
Western Blot (WB)
(CTNND2 monoclonal antibody. Western Blot analysis of CTNND2 expression in PC-12.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome.[provided by RefSeq, Aug 2010]
Uniprot Description
Function: Functions as a transcriptional activator when bound to ZBTB33
By similarity. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Ref.2
Subunit structure: Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33
By similarity. Binds to PSEN1. Interacts with ARHGEF28. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). Ref.1 Ref.3 Ref.7 Ref.12 Ref.13 Ref.14
Subcellular location: Nucleus
By similarity. Cell junction › adherens junction
By similarity. Perikaryon. Note: Colocalizes with CDK5 in the cell body of neuronal cells.
Tissue specificity: Predominantly expressed in brain; accumulates in cortical neurons (at protein level). Ref.12
Post-translational modification: O-glycosylated
By similarity.Phosphorylated by CDK5. Ref.12
Sequence similarities: Belongs to the beta-catenin family.Contains 9 ARM repeats.
Sequence caution: The sequence AAB68599.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAB88185.1 differs from that shown. Reason: Frameshift at position 913.
Research Articles on CTNND2
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Product Notes
The CTNND2 ctnnd2 (Catalog #AAA646128) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CTNND2 (Catenin delta-2, Delta-catenin, GT24, Neural Plakophilin-related ARM-repeat Protein, NPRAP, Neurojungin, NPRAP) reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CTNND2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Researchers should empirically determine the suitability of the CTNND2 ctnnd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: ISLKERKTDY ECTGSNATYH GAKGEHTSRK DAMTAQNTGI STLYRNSYGA PAEDIKHNQV SAQPVPQEPS RKDYETYQPF QNSTRNYDES FFEDQVHHRP PASEYTMHLG. It is sometimes possible for the material contained within the vial of "CTNND2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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