Rabbit anti-Human CTHRC1  Monoclonal Antibody | anti-CTHRC1  antibody

Rabbit anti Human CTHRC1  Monoclonal Antibody

Cat. Num. AAA2544271

• Reactivity: Human
• Applications: Western Blot, Immunoprecipitation
• Synonyms: CTHRC1 ; Monoclonal Antibody; Rabbit anti Human CTHRC1 Monoclonal Antibody; anti-CTHRC1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 229

• Applicable Applications for anti-CTHRC1 antibody: Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: WB: 5-10 mug/mL; IP: 1-4 mug/mg of lysate
• Immunogen: Recombinant Human CTHRC1 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CTHRC1  antibody

Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to be responsible for trimerization of the CTHRC1 protein and this renders the molecule susceptible to cleavage by collagenase. CTHRC1 overexpression caused a dramatic reduction in collagen type I mRNA and protein levels. Currently available data indicate that Cthrc1 expression in vascular cells regulates transforming growth factor beta responsiveness, thereby impacting transforming growth factor beta target genes, including collagens. Additionally, CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis.

NCBI and Uniprot Product Information

• NCBI GI #: 368711292
• NCBI GeneID: 115908
• NCBI GenBank Nucleotide #: NM_001256099.1
• Molecular Weight: 24,770 Da
• NCBI Official Full Name: collagen triple helix repeat-containing protein 1 isoform 2
• NCBI Official Synonym Full Names: collagen triple helix repeat containing 1
• NCBI Official Symbol: CTHRC1
• NCBI Protein Information: collagen triple helix repeat-containing protein 1
• UniProt Protein Name: Collagen triple helix repeat-containing protein 1
• UniProt Gene Name: CTHRC1
• UniProt Entry Name: CTHR1_HUMAN

NCBI Description

This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

Uniprot Description

CTHRC1: May act as a negative regulator of collagen matrix deposition. Defects in CTHRC1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in CTHRC1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q22.3

Cellular Component: extracellular space

Disease: Barrett Esophagus