Mouse anti-Human, Mouse CSNK2B Monoclonal Antibody | anti-CSNK2B antibody

CSNK2B (CSNK2B, CK2N, G5A, Casein kinase II subunit beta, Phosvitin, Protein G5a) (Biotin)

Cat. Num. AAA6121161

• Gene Names: CSNK2B; G5A; CK2B; CK2N; CSK2B
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Purified by Protein G Affinity Chromatography
• Synonyms: CSNK2B; Monoclonal Antibody; CSNK2B (CSNK2B; CK2N; G5A; Casein kinase II subunit beta; Phosvitin; Protein G5a) (Biotin); Protein G5a; anti-CSNK2B antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 260CT10.1.1
• Purity/Purification: Purified by Protein G Affinity Chromatography
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-CSNK2B antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: ELISA: 1:1000; WB: 1:100; Applications are based on unconjugated antibody.
• Immunogen: CSNK2B Mab is generated from mouse immunized with CSNK2B recombinant protein.
• Conjugate: Biotin
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(CSNK2B Antibody western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CSNK2B antibody detected the CSNK2B protein (arrow).)

Western Blot (WB)

(CSNK2B Antibody western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the CSNK2B antibody detected the CSNK2B protein (arrow).)

Related Product Information for anti-CSNK2B antibody

This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.

Product Categories/Family for anti-CSNK2B antibody

Antibodies; Protein Kinases

References

Shehata, M., et al. Blood 116(14):2513-2521(2010) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Olsen, B.B., et al. Int. J. Oncol. 36(5):1175-1182(2010) Shi, Y., et al. BMB Rep 42(12):840-845(2009) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

NCBI and Uniprot Product Information

• NCBI GI #: 23503295
• NCBI GeneID: 1460
• NCBI Accession #: NP_001311.3
• NCBI GenBank Nucleotide #: NM_001320.5
• UniProt Accession #: P67870; P07312; P13862; Q4VX47; B0UXA9
• Molecular Weight: 24,942 Da
• NCBI Official Full Name: casein kinase II subunit beta
• NCBI Official Synonym Full Names: casein kinase 2, beta polypeptide
• NCBI Official Symbol: CSNK2B
• NCBI Official Synonym Symbols: G5A; CK2B; CK2N; CSK2B
• NCBI Protein Information: casein kinase II subunit beta; phosvitin; CK II beta; protein G5a; Casein kinase II beta subunit; alternative name: G5a, phosvitin
• UniProt Protein Name: Casein kinase II subunit beta
• UniProt Gene Name: CSNK2B
• UniProt Synonym Gene Names: CK2N; G5A; CK II beta
• UniProt Entry Name: CSK2B_HUMAN

NCBI Description

This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. [provided by RefSeq, Jul 2008]

Uniprot Description

CK2B: a regulatory subunit of the casein kinase 2 holoenzyme. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. Plays a complex role in regulating the basal catalytic activity of the alpha subunit. Participates in Wnt signaling

Protein type: Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cytoplasm; plasma membrane; protein kinase CK2 complex; PcG protein complex; nucleus; cytosol

Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein domain specific binding; protein binding; metal ion binding; protein kinase regulator activity; transcription factor binding; receptor binding

Biological Process: negative regulation of cell proliferation; axon guidance; positive regulation of activin receptor signaling pathway; Wnt receptor signaling pathway; cellular protein complex assembly; regulation of DNA binding; adiponectin-mediated signaling pathway; mitotic cell cycle; regulation of protein kinase activity; negative regulation of blood vessel endothelial cell migration; signal transduction; protein amino acid phosphorylation