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Testing Data
(Figure 1. Expi 293 cell line transfected with irrelevant protein (left) and human CS1 (right) were surface stained with Rabbit anti-CS1monoclonal antibody 15ug/ml (clone: DM11) followed by Alexa 488-conjugated anti-rabbit IgG secondary antibody. )
Rabbit anti-Human CS1 Monoclonal Antibody | anti-CS1 antibody
Anti-CS1 antibody (DM11), Rabbit mAb
Gene Names
SLAMF7; 19A; CS1; CD319; CRACC
Reactivity
Human
Applications
ELISA, Flow Cytometry, Functional Assay, Immunoprecipitation, Immunofluorescence
Purity
Purified from cell culture supernatant by affinity chromatography
Synonyms
CS1; Monoclonal Antibody; Anti-CS1 antibody (DM11); Rabbit mAb; SLAM7 (19A; CD319; CRACC; CS1); anti-CS1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
DM11
Purity/Purification
Purified from cell culture supernatant by affinity chromatography
Form/Format
Liquid; 0.1% Procline 300; 50% Glycerol; PBS, pH7.4; 0.1% BSA
Applicable Applications for anti-CS1 antibody
ELISA (EIA), Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunofluorescence (IF)
Application Notes
FC:FACS: 1:100
Immunogen
Recombinant human CS1 (Ser23-Met226) produced by using human HEK293 cells
Reconstitution
Reconstitute with deionized water
Preservative
0.1% Procline 300
Constituents
50% Glycerol; PBS, pH 7.4; 0.1% BSA
Preparation and Storage
Store at -20 degree C for 12 months (Avoid repeated freezing and thawing)
Shipping: Blue Ice
Shipping: Blue Ice
Testing Data
(Figure 1. Expi 293 cell line transfected with irrelevant protein (left) and human CS1 (right) were surface stained with Rabbit anti-CS1monoclonal antibody 15ug/ml (clone: DM11) followed by Alexa 488-conjugated anti-rabbit IgG secondary antibody. )
Testing Data
(Figure 1. Expi 293 cell line transfected with irrelevant protein (left) and human CS1 (right) were surface stained with Rabbit anti-CS1monoclonal antibody 15ug/ml (clone: DM11) followed by Alexa 488-conjugated anti-rabbit IgG secondary antibody. )
Flow Cytometry (FC/FACS)
(Figure 2. Flow cytometry data of serially titrated Rabbit anti-CS1 monoclonal antibody (clone: DM11) on Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. )
Flow Cytometry (FC/FACS)
(Figure 2. Flow cytometry data of serially titrated Rabbit anti-CS1 monoclonal antibody (clone: DM11) on Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. )
Testing Data
(Figure 3. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.)
Testing Data
(Figure 3. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.)
Testing Data
(Figure 4. Phylogenetic analysis of amino acid sequence of different Rabbit Anti-CS1 mAb clones. A) Heavy chain and B) Light chain.)
Testing Data
(Figure 4. Phylogenetic analysis of amino acid sequence of different Rabbit Anti-CS1 mAb clones. A) Heavy chain and B) Light chain.)
Related Product Information for anti-CS1 antibody
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
Product Categories/Family for anti-CS1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
21,316 Da
NCBI Official Full Name
SLAM family member 7 isoform b
NCBI Official Synonym Full Names
SLAM family member 7
NCBI Official Symbol
SLAMF7
NCBI Official Synonym Symbols
19A; CS1; CD319; CRACC
NCBI Protein Information
SLAM family member 7
UniProt Protein Name
SLAM family member 7
Protein Family
UniProt Gene Name
SLAMF7
UniProt Synonym Gene Names
CS1; CRACC
UniProt Entry Name
SLAF7_HUMAN
Uniprot Description
SLAMF7: Isoform 1 mediates NK cell activation through a SH2D1A- independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q23.1-q24.1
Cellular Component: plasma membrane
Biological Process: regulation of immune response
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Product Notes
The CS1 slamf7 (Catalog #AAA188032) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CS1 antibody (DM11), Rabbit mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CS1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunofluorescence (IF). FC:FACS: 1:100. Researchers should empirically determine the suitability of the CS1 slamf7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CS1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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